8bpc: Difference between revisions

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'''Unreleased structure'''


The entry 8bpc is ON HOLD  until Paper Publication
==Cryo-EM structure of the human SIN3B histone deacetylase core complex with SAHA at 2.8 Angstrom==
 
<StructureSection load='8bpc' size='340' side='right'caption='[[8bpc]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
Authors:  
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8bpc]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BPC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BPC FirstGlance]. <br>
Description:  
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SHH:OCTANEDIOIC+ACID+HYDROXYAMIDE+PHENYLAMIDE'>SHH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8bpc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8bpc OCA], [https://pdbe.org/8bpc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8bpc RCSB], [https://www.ebi.ac.uk/pdbsum/8bpc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8bpc ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/SIN3B_HUMAN SIN3B_HUMAN] SIN3A-related intellectual disability syndrome due to a point mutation.
== Function ==
[https://www.uniprot.org/uniprot/SIN3B_HUMAN SIN3B_HUMAN] Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription. With FOXK1, regulates cell cycle progression probably by repressing cell cycle inhibitor genes expression.[UniProtKB:Q62141]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Alfieri C]]
[[Category: Koliopolous MG]]
[[Category: Muhammad R]]
[[Category: Wan MSM]]

Revision as of 09:51, 10 May 2023

Cryo-EM structure of the human SIN3B histone deacetylase core complex with SAHA at 2.8 AngstromCryo-EM structure of the human SIN3B histone deacetylase core complex with SAHA at 2.8 Angstrom

Structural highlights

8bpc is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

SIN3B_HUMAN SIN3A-related intellectual disability syndrome due to a point mutation.

Function

SIN3B_HUMAN Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription. With FOXK1, regulates cell cycle progression probably by repressing cell cycle inhibitor genes expression.[UniProtKB:Q62141]

8bpc, resolution 2.80Å

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OCA
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