7uyq: Difference between revisions

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-'''Unreleased structure'''
-The entry 7uyq is ON HOLD  until 2024-05-07
+==Structure of GTP binds to Cyclic GMP AMP synthase (cGAS) through Mg coordination==
+<StructureSection load='7uyq' size='340' side='right'caption='[[7uyq]], [[Resolution|resolution]] 2.57&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[7uyq]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/DNA_molecule DNA molecule] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UYQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7UYQ FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7uyq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7uyq OCA], [https://pdbe.org/7uyq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7uyq RCSB], [https://www.ebi.ac.uk/pdbsum/7uyq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7uyq ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/CGAS_MOUSE CGAS_MOUSE] Nucleotidyltransferase that catalyzes formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and exhibits antiviral activity. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of DNA in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.
+__TOC__
+</StructureSection>
+[[Category: DNA molecule]]
+[[Category: Large Structures]]
+[[Category: Mus musculus]]
+[[Category: Gabelli SB]]
+[[Category: Sohn J]]
+[[Category: Wu S]]