1kqf: Difference between revisions

Revision as of 23:02, 2 May 2008

FORMATE DEHYDROGENASE N FROM E. COLI

OverviewOverview

The structure of the membrane protein formate dehydrogenase-N (Fdn-N), a major component of Escherichia coli nitrate respiration, has been determined at 1.6 angstroms. The structure demonstrates 11 redox centers, including molybdopterin-guanine dinucleotides, five [4Fe-4S] clusters, two heme b groups, and a menaquinone analog. These redox centers are aligned in a single chain, which extends almost 90 angstroms through the enzyme. The menaquinone reduction site associated with a possible proton pathway was also characterized. This structure provides critical insights into the proton motive force generation by redox loop, a common mechanism among a wide range of respiratory enzymes.

About this StructureAbout this Structure

1KQF is a Protein complex structure of sequences from Escherichia coli. Full crystallographic information is available from OCA.

ReferenceReference

Molecular basis of proton motive force generation: structure of formate dehydrogenase-N., Jormakka M, Tornroth S, Byrne B, Iwata S, Science. 2002 Mar 8;295(5561):1863-8. PMID:11884747 Page seeded by OCA on Fri May 2 23:02:46 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
 [[Image:1kqf.gif|left|200px]]
- {{Structure
+<!--
-|PDB= 1kqf |SIZE=350|CAPTION= <scene name='initialview01'>1kqf</scene>, resolution 1.60&Aring;
+The line below this paragraph, containing "STRUCTURE_1kqf", creates the "Structure Box" on the page.
-|SITE=
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=6MO:MOLYBDENUM(VI)+ION'>6MO</scene>, <scene name='pdbligand=CDL:CARDIOLIPIN'>CDL</scene>, <scene name='pdbligand=CSE:SELENOCYSTEINE'>CSE</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=MGD:2-AMINO-5,6-DIMERCAPTO-7-METHYL-3,7,8A,9-TETRAHYDRO-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-4-ONE+GUANOSINE+DINUCLEOTIDE'>MGD</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene>
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Formate_dehydrogenase Formate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.2 1.2.1.2] </span>
+or leave the SCENE parameter empty for the default display.
-|GENE=
+-->
-|DOMAIN=
+{{STRUCTURE_1kqf|  PDB=1kqf  |  SCENE=  }}
-|RELATEDENTRY=[[1kqg|1KQG]]
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kqf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kqf OCA], [http://www.ebi.ac.uk/pdbsum/1kqf PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1kqf RCSB]</span>
-}}
 '''FORMATE DEHYDROGENASE N FROM E. COLI'''
@@ Line 30: / Line 27: @@
 [[Category: Jormakka, M.]]
 [[Category: Tornroth, S.]]
-[[Category: anaerobic]]
+[[Category: Anaerobic]]
-[[Category: dehydrogenase]]
+[[Category: Dehydrogenase]]
-[[Category: fe4s4]]
+[[Category: Fe4s4]]
-[[Category: formate]]
+[[Category: Formate]]
-[[Category: integral membrane protein]]
+[[Category: Integral membrane protein]]
-[[Category: iron sulfur cluster]]
+[[Category: Iron sulfur cluster]]
-[[Category: mgd]]
+[[Category: Mgd]]
-[[Category: molybdenum]]
+[[Category: Molybdenum]]
-[[Category: molybdopterin]]
+[[Category: Molybdopterin]]
-[[Category: molybdopterin guanine dinucleotide]]
+[[Category: Molybdopterin guanine dinucleotide]]
-[[Category: mpt]]
+[[Category: Mpt]]
-[[Category: oxidoreductase]]
+[[Category: Oxidoreductase]]
-[[Category: secy]]
+[[Category: Secy]]
-[[Category: selenium]]
+[[Category: Selenium]]
-[[Category: selenocysteine]]
+[[Category: Selenocysteine]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 23:02:46 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:52:08 2008''