4yo2: Difference between revisions

<table><tr><td colspan='2'>[[4yo2]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YO2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YO2 FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4yo2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yo2 OCA], [https://pdbe.org/4yo2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4yo2 RCSB], [https://www.ebi.ac.uk/pdbsum/4yo2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4yo2 ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/E2F8_HUMAN E2F8_HUMAN] Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1: component of a feedback loop in S phase by repressing the expression of E2F1, thereby preventing p53/TP53-dependent apoptosis. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene.<ref>PMID:15897886</ref> <ref>PMID:16179649</ref> <ref>PMID:18202719</ref> <ref>PMID:22903062</ref>  

[[Category: Homo sapiens]]

[[Category: Dave K]]

[[Category: Eremina N]]

[[Category: Jolma A]]

[[Category: Morgunova E]]

[[Category: Nilsson L]]

[[Category: Popov A]]

[[Category: Schmierer B]]

[[Category: Taipale J]]

[[Category: Yin Y]]