4ynh: Difference between revisions
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<StructureSection load='4ynh' size='340' side='right'caption='[[4ynh]], [[Resolution|resolution]] 1.00Å' scene=''> | <StructureSection load='4ynh' size='340' side='right'caption='[[4ynh]], [[Resolution|resolution]] 1.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4ynh]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4ynh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YNH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YNH FirstGlance]. <br> | ||
</td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ynh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ynh OCA], [https://pdbe.org/4ynh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ynh RCSB], [https://www.ebi.ac.uk/pdbsum/4ynh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ynh ProSAT]</span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/SAS5_CAEEL SAS5_CAEEL] Required for centrosome duplication. Essential for daughter-centriole formation. Requires both maternal and partenal expression, suggesting that it regulates centriole duplication during both spermatogenesis and early embryogenesis.<ref>PMID:15232593</ref> <ref>PMID:15572125</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Caenorhabditis elegans]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Hatzopoulos | [[Category: Hatzopoulos GN]] | ||
[[Category: Rogala | [[Category: Rogala KB]] | ||
[[Category: Vakonakis | [[Category: Vakonakis I]] | ||
Revision as of 11:21, 3 May 2023
Structure of the C. elegans SAS-5 Implico dimerization domainStructure of the C. elegans SAS-5 Implico dimerization domain
Structural highlights
FunctionSAS5_CAEEL Required for centrosome duplication. Essential for daughter-centriole formation. Requires both maternal and partenal expression, suggesting that it regulates centriole duplication during both spermatogenesis and early embryogenesis.[1] [2] Publication Abstract from PubMedCentrioles are microtubule-based organelles crucial for cell division, sensing and motility. In C. elegans, the onset of centriole formation requires notably the proteins SAS-5 and SAS-6, which have functional homologs across eukaryotic evolution. Whereas the molecular architecture of SAS-6 and its role in initiating centriole formation are well understood, the mechanisms by which SAS-5 and its relatives function is unclear. Here, we combine biophysical and structural analysis to uncover the architecture of SAS-5 and examine its functional implications in vivo. Our work reveals that two distinct self-associating domains are necessary to form higher-order oligomers of SAS-5: a trimeric coiled coil and a novel globular dimeric Implico domain. Disruption of either domain leads to centriole duplication failure in worm embryos, indicating that large SAS-5 assemblies are necessary for function in vivo. The protein SAS-5 forms large oligomeric assemblies critical for centriole formation.,Rogala KB, Dynes NJ, Hatzopoulos GN, Yan J, Pong SK, Robinson CV, Deane CM, Gonczy P, Vakonakis I Elife. 2015 May 29;4. doi: 10.7554/eLife.07410. PMID:26023830[3] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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