1kog: Difference between revisions

Revision as of 22:59, 2 May 2008

Crystal structure of E. coli threonyl-tRNA synthetase interacting with the essential domain of its mRNA operator

OverviewOverview

Escherichia coli threonyl-tRNA synthetase (ThrRS) represses the translation of its own messenger RNA by binding to an operator located upstream of the initiation codon. The crystal structure of the complex between the core of ThrRS and the essential domain of the operator shows that the mRNA uses the recognition mode of the tRNA anticodon loop to initiate binding. The final positioning of the operator, upon which the control mechanism is based, relies on a characteristic RNA motif adapted to the enzyme surface. The finding of other thrS operators that have this conserved motif leads to a generalization of this regulatory mechanism to a subset of Gram-negative bacteria.

About this StructureAbout this Structure

1KOG is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

ReferenceReference

Structural basis of translational control by Escherichia coli threonyl tRNA synthetase., Torres-Larios A, Dock-Bregeon AC, Romby P, Rees B, Sankaranarayanan R, Caillet J, Springer M, Ehresmann C, Ehresmann B, Moras D, Nat Struct Biol. 2002 May;9(5):343-7. PMID:11953757 Page seeded by OCA on Fri May 2 22:59:00 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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 [[Image:1kog.gif|left|200px]]
- {{Structure
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+The line below this paragraph, containing "STRUCTURE_1kog", creates the "Structure Box" on the page.
-|SITE=
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=TSB:5&#39;-O-(N-(L-THREONYL)-SULFAMOYL)ADENOSINE'>TSB</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Threonine--tRNA_ligase Threonine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.3 6.1.1.3] </span>
+or leave the SCENE parameter empty for the default display.
-|GENE=
+-->
-|DOMAIN=
+{{STRUCTURE_1kog|  PDB=1kog  |  SCENE=  }}
-|RELATEDENTRY=[[1evl|1EVL]], [[1qf6|1QF6]]
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kog FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kog OCA], [http://www.ebi.ac.uk/pdbsum/1kog PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1kog RCSB]</span>
-}}
 '''Crystal structure of E. coli threonyl-tRNA synthetase interacting with the essential domain of its mRNA operator'''
@@ Line 36: / Line 33: @@
 [[Category: Springer, M.]]
 [[Category: Torres-Larrios, A.]]
-[[Category: protein-rna complex]]
+[[Category: Protein-rna complex]]
-[[Category: rna base triple]]
+[[Category: Rna base triple]]
-[[Category: rna double helix]]
+[[Category: Rna double helix]]
-[[Category: rna stem-loop]]
+[[Category: Rna stem-loop]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 22:59:00 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:51:26 2008''