1kn3: Difference between revisions

Revision as of 22:56, 2 May 2008

Murine PEBP-2 (phosphatidylethanolamine-binding protein-2)

OverviewOverview

Proteins from the PEBP (phosphatidylethanolamine-binding protein) family have been identified in a wide variety of species and are thought to regulate a range of intracellular signalling cascades. The rat homologue (known as RKIP; Raf-1 kinase inhibitor protein) has been shown to negatively regulate the MAP kinase pathway through formation of inhibitory complexes with Raf-1 and MEK. The crystal structure of a new, murine member of the PEBP family, termed mPEBP-2, has been determined. On the basis of amino-acid homology, mPEBP-2 belongs to a distinct subset of the mammalian PEBP proteins. Nonetheless, mPEBP-2 is seen to be very similar in structure to other PEBP proteins from human, bovine and plant sources. Regions of distinctive sequence associated with the PEBP-2 subset are discussed with reference to this structure.

About this StructureAbout this Structure

1KN3 is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

ReferenceReference

The crystal structure of PEBP-2, a homologue of the PEBP/RKIP family., Simister PC, Banfield MJ, Brady RL, Acta Crystallogr D Biol Crystallogr. 2002 Jun;58(Pt 6 Pt 2):1077-80. Epub, 2002 May 29. PMID:12037323 Page seeded by OCA on Fri May 2 22:56:05 2008

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OCA

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 [[Image:1kn3.gif|left|200px]]
- {{Structure
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-|GENE= pebp-2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
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-|DOMAIN=
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-|RELATEDENTRY=[[1bd9|1BD9]], [[1beh|1BEH]], [[1a44|1A44]], [[1qou|1QOU]], [[1fjj|1FJJ]], [[1fuc|1FUC]]
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kn3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kn3 OCA], [http://www.ebi.ac.uk/pdbsum/1kn3 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1kn3 RCSB]</span>
-}}
 '''Murine PEBP-2 (phosphatidylethanolamine-binding protein-2)'''
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 [[Category: Brady, R L.]]
 [[Category: Simister, P C.]]
-[[Category: cis-peptide]]
+[[Category: Cis-peptide]]
-[[Category: phosphatidylethanolamine binding]]
+[[Category: Phosphatidylethanolamine binding]]
-[[Category: raf-1 kinase inhibitor]]
+[[Category: Raf-1 kinase inhibitor]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 22:56:05 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:50:52 2008''