8g6a: Difference between revisions

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-'''Unreleased structure'''
-The entry 8g6a is ON HOLD  until Paper Publication
+==Wildtype PTP1b in complex with DES6016==
+<StructureSection load='8g6a' size='340' side='right'caption='[[8g6a]], [[Resolution|resolution]] 1.62&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8g6a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8G6A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8G6A FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=ZD3:{(2S)-4-[6-methyl-2-(trifluoromethyl)quinolin-4-yl]piperazin-2-yl}methanol'>ZD3</scene>, <scene name='pdbligand=ZD5:{(2R)-4-[6-methyl-2-(trifluoromethyl)quinolin-4-yl]piperazin-2-yl}methanol'>ZD5</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8g6a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8g6a OCA], [https://pdbe.org/8g6a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8g6a RCSB], [https://www.ebi.ac.uk/pdbsum/8g6a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8g6a ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/PTN1_HUMAN PTN1_HUMAN] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.<ref>PMID:21135139</ref> <ref>PMID:22169477</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Giordanetto F]]
+[[Category: Greisman JB]]
+[[Category: Maragakis P]]
+[[Category: Nisonoff H]]
+[[Category: Shahamadtar S]]
+[[Category: Shaw DE]]
+[[Category: Willmore L]]
+[[Category: Yeh CY]]