Sandbox Reserved 1790: Difference between revisions

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OCA, Jaime Prilusky, Inaya Patel, Rushda Hussein, Madeline Gilbert

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 ===Future Studies===
-With this understood knowledge about how the SMP is able to contribute to an increase or decrease of MAPK pathways, there can be further research done to develop treatments for various cancers and rasopathies <ref name="Liau" />. Research can be done to develop [https://www.sciencedirect.com/topics/earth-and-planetary-sciences/enzyme-inhibitor. inhibitors] that can alter the affinity of the SMP complex in order to regulate MAPK signaling pathways. This can help treat diseases that are caused by unregulated cell proliferation <ref name="Lavoie">. Another possible point of inhibition is the growth factor that signals SHOC2-PP1C and Raf to the cell membrane. <ref name="Liau" /> .
+With this understood knowledge about how the SMP is able to contribute to an increase or decrease of MAPK pathways, there can be further research done to develop treatments for various cancers and rasopathies <ref name="Liau" />. Research can be done to develop [https://www.sciencedirect.com/topics/earth-and-planetary-sciences/enzyme-inhibitor. inhibitors] that can alter the affinity of the SMP complex in order to regulate MAPK signaling pathways. This can help treat diseases that are caused by unregulated cell proliferation <ref name="Lavoie">. Another possible point of inhibition is the growth factor that signals SHOC2-PP1C and Raf to the cell membrane. <ref name="Liau" />.
 [[Image:Complex.png|800 px|thumb|center|'''Figure 3:'''Signaling cascade is shown with SHOC2 (magenta), PP1C (blue), and MRAS (white). SHOC2 binds to PP1C then to MRAS at the cell membrane. The SMP complex is now oriented near the membrane-bound RAF complex (green) allowing PP1C to phosphorylate RAF at serine 259.]]