4xi0: Difference between revisions
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<StructureSection load='4xi0' size='340' side='right'caption='[[4xi0]], [[Resolution|resolution]] 2.88Å' scene=''> | <StructureSection load='4xi0' size='340' side='right'caption='[[4xi0]], [[Resolution|resolution]] 2.88Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4xi0]] is a 6 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4xi0]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Solidesulfovibrio_magneticus_RS-1 Solidesulfovibrio magneticus RS-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XI0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XI0 FirstGlance]. <br> | ||
</td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xi0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xi0 OCA], [https://pdbe.org/4xi0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xi0 RCSB], [https://www.ebi.ac.uk/pdbsum/4xi0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xi0 ProSAT]</span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/C4XPQ7_SOLM1 C4XPQ7_SOLM1] | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Baran | [[Category: Solidesulfovibrio magneticus RS-1]] | ||
[[Category: Cronin | [[Category: Baran D]] | ||
[[Category: Davidov | [[Category: Cronin S]] | ||
[[Category: Stein | [[Category: Davidov G]] | ||
[[Category: Zarivach | [[Category: Stein T]] | ||
[[Category: Zeytuni | [[Category: Zarivach R]] | ||
[[Category: Zeytuni N]] | |||
Revision as of 12:59, 19 April 2023
MamA 41-end from Desulfovibrio magneticus RS-1MamA 41-end from Desulfovibrio magneticus RS-1
Structural highlights
FunctionPublication Abstract from PubMedMamA is a highly conserved protein found in magnetotactic bacteria (MTB), a diverse group of prokaryotes capable of navigating according to magnetic fields - an ability known as magnetotaxis. Questions surround the acquisition of this magnetic navigation ability; namely, whether it arose through horizontal or vertical gene transfer. Though its exact function is unknown, MamA surrounds the magnetosome, the magnetic organelle embedding a biomineralised nanoparticle and responsible for magnetotaxis. Several structures for MamA from a variety of species have been determined and show a high degree of structural similarity. By determining the structure of MamA from Desulfovibrio magneticus RS-1 using X-ray crystallography, we have opened up the structure-sequence landscape. As such, this allows us to perform structural- and phylogenetic-based analyses using a variety of previously determined MamA from a diverse range of MTB species across various phylogenetic groups. We found that MamA has remained remarkably constant throughout evolution with minimal change between different taxa despite sequence variations. These findings, coupled with the generation of phylogenetic trees using both amino acid sequences and 16S rRNA, indicate that magnetotaxis likely did not spread via horizontal gene transfer and instead has a significantly earlier, primordial origin. MamA as a Model Protein for Structure-Based Insight into the Evolutionary Origins of Magnetotactic Bacteria.,Zeytuni N, Cronin S, Lefevre CT, Arnoux P, Baran D, Shtein Z, Davidov G, Zarivach R PLoS One. 2015 Jun 26;10(6):e0130394. doi: 10.1371/journal.pone.0130394., eCollection 2015. PMID:26114501[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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