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| <StructureSection load='4xh9' size='340' side='right'caption='[[4xh9]], [[Resolution|resolution]] 2.00Å' scene=''> | | <StructureSection load='4xh9' size='340' side='right'caption='[[4xh9]], [[Resolution|resolution]] 2.00Å' scene=''> |
| == Structural highlights == | | == Structural highlights == |
| <table><tr><td colspan='2'>[[4xh9]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XH9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XH9 FirstGlance]. <br> | | <table><tr><td colspan='2'>[[4xh9]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XH9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XH9 FirstGlance]. <br> |
| </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NET1, ARHGEF8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), RHOA, ARH12, ARHA, RHO12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xh9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xh9 OCA], [https://pdbe.org/4xh9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xh9 RCSB], [https://www.ebi.ac.uk/pdbsum/4xh9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xh9 ProSAT]</span></td></tr> |
| <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xh9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xh9 OCA], [http://pdbe.org/4xh9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xh9 RCSB], [http://www.ebi.ac.uk/pdbsum/4xh9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xh9 ProSAT]</span></td></tr> | |
| </table> | | </table> |
| == Function == | | == Function == |
| [[http://www.uniprot.org/uniprot/ARHG8_HUMAN ARHG8_HUMAN]] Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway Stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death.<ref>PMID:21373644</ref> [[http://www.uniprot.org/uniprot/RHOA_HUMAN RHOA_HUMAN]] Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. Stimulates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization.<ref>PMID:8910519</ref> <ref>PMID:9121475</ref> <ref>PMID:12900402</ref> <ref>PMID:16103226</ref> <ref>PMID:16236794</ref> <ref>PMID:19934221</ref> <ref>PMID:20937854</ref> <ref>PMID:20974804</ref> | | [https://www.uniprot.org/uniprot/ARHG8_HUMAN ARHG8_HUMAN] Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway Stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death.<ref>PMID:21373644</ref> |
| <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| ==See Also== | | ==See Also== |
| *[[Rho GTPase|Rho GTPase]] | | *[[Rho GTPase 3D structures|Rho GTPase 3D structures]] |
| *[[Rho guanine nucleotide exchange factor|Rho guanine nucleotide exchange factor]] | | *[[Rho guanine nucleotide exchange factor 3D structures|Rho guanine nucleotide exchange factor 3D structures]] |
| == References == | | == References == |
| <references/> | | <references/> |
| __TOC__ | | __TOC__ |
| </StructureSection> | | </StructureSection> |
| [[Category: Human]] | | [[Category: Homo sapiens]] |
| [[Category: Large Structures]] | | [[Category: Large Structures]] |
| [[Category: Boutin, J A]] | | [[Category: Boutin JA]] |
| [[Category: Ferry, G]] | | [[Category: Ferry G]] |
| [[Category: Garcia, C]] | | [[Category: Garcia C]] |
| [[Category: Petit, P]] | | [[Category: Petit P]] |
| [[Category: Vuillard, L]] | | [[Category: Vuillard L]] |
| [[Category: Activator]]
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| [[Category: Guanine nucleotide exchange factor]]
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| [[Category: Rhoa gtpase]]
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| [[Category: Signaling protein]]
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