7f9b: Difference between revisions

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-'''Unreleased structure'''
-The entry 7f9b is ON HOLD  until 2023-10-04
+==Homo sapiens Prolyl-tRNA Synthetase (HsPRS) in Complex with L-proline and compound L95==
+<StructureSection load='7f9b' size='340' side='right'caption='[[7f9b]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-Authors: Manickam, Y., Malhotra, N., Sharma, A.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[7f9b]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7F9B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7F9B FirstGlance]. <br>
-Description: Homo sapiens Prolyl-tRNA Synthetase (HsPRS) in Complex with L-proline and compound L95
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=JE6:~{N}-[4-[(3~{S})-3-cyano-3-cyclopropyl-2-oxidanylidene-pyrrolidin-1-yl]-6-methyl-pyridin-2-yl]-2-phenyl-ethanamide'>JE6</scene>, <scene name='pdbligand=PRO:PROLINE'>PRO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7f9b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7f9b OCA], [https://pdbe.org/7f9b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7f9b RCSB], [https://www.ebi.ac.uk/pdbsum/7f9b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7f9b ProSAT]</span></td></tr>
-[[Category: Malhotra, N]]
+</table>
-[[Category: Sharma, A]]
+== Function ==
-[[Category: Manickam, Y]]
+[https://www.uniprot.org/uniprot/SYEP_HUMAN SYEP_HUMAN] Catalyzes the attachment of the cognate amino acid to the corresponding tRNA in a two-step reaction: the amino acid is first activated by ATP to form a covalent intermediate with AMP and is then transferred to the acceptor end of the cognate tRNA. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the multisynthetase complex and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation.<ref>PMID:1756734</ref> <ref>PMID:15479637</ref> <ref>PMID:23071094</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Malhotra N]]
+[[Category: Manickam Y]]
+[[Category: Sharma A]]