7qpv: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
← Older editNewer edit →
m Protected "7qpv" [edit=sysop:move=sysop]
No edit summary
Line 1: Line 1:
'''Unreleased structure'''


The entry 7qpv is ON HOLD  until Paper Publication
==Discovery of Lu AF11167, a Phosphodiesterase 10A inhibitor clinical candidate==
 
<StructureSection load='7qpv' size='340' side='right'caption='[[7qpv]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
Authors: Leonard, P.M., Langgard, M.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[7qpv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QPV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QPV FirstGlance]. <br>
Description: Discovery of Lu AF11167, a Phosphodiesterase 10A inhibitor clinical candidate
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EHI:8-methyl-2-[2-(1-methyl-4-phenyl-imidazol-2-yl)ethyl]-[1,2,4]triazolo[1,5-a]pyridine'>EHI</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qpv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qpv OCA], [https://pdbe.org/7qpv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qpv RCSB], [https://www.ebi.ac.uk/pdbsum/7qpv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qpv ProSAT]</span></td></tr>
[[Category: Langgard, M]]
</table>
[[Category: Leonard, P.M]]
== Function ==
[https://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Langgard M]]
[[Category: Leonard PM]]

Revision as of 12:19, 19 April 2023

Discovery of Lu AF11167, a Phosphodiesterase 10A inhibitor clinical candidateDiscovery of Lu AF11167, a Phosphodiesterase 10A inhibitor clinical candidate

Structural highlights

7qpv is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PDE10_HUMAN Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.[1]

References

  1. ↑ Wang H, Liu Y, Hou J, Zheng M, Robinson H, Ke H. Structural insight into substrate specificity of phosphodiesterase 10. Proc Natl Acad Sci U S A. 2007 Apr 3;104(14):5782-7. Epub 2007 Mar 26. PMID:17389385

7qpv, resolution 2.30Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=7qpv&oldid=3754543"