Sandbox Reserved 1788: Difference between revisions
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= Introduction = | = Introduction = | ||
[[Image:SMP complex.jpg|300 px|right|thumb|'''Figure 1:'''Overall cartoon of SHOC2-PP1C-MRAS structure with SHOC2 in pink, PP1C in blue, and MRAs in white.</div></font>]] | [[Image:SMP complex.jpg|300 px|right|thumb|'''Figure 1:'''Overall cartoon of SHOC2-PP1C-MRAS structure with SHOC2 in pink, PP1C in blue, and MRAs in white.</div></font>]] | ||
<scene name='95/ | <scene name='95/952716/Zoom_out/1'>SHOC2-PP1C-MRAS</scene> (SMP) is a ternary holoposphatase complex formed by the individual proteins: SHOC2, PP1C, and MRAS. Formation of this complex begins with a signal binding to a receptor tyrosine kinase receptor(RTK). This causes membrane-bound MRAS to exchange GDP for GTP. From here the complex comes together in the plasma membrane. Its role in MAPK signaling is the dephosphorylation of the N-terminal phosphoserine (NTpS) on the RAF complex leading to further downstream signaling effects. | ||
<scene name='95/952716/Mras_and_pp1c/2'>TextToBeDisplayed</scene> | <scene name='95/952716/Mras_and_pp1c/2'>TextToBeDisplayed</scene> | ||