1kjw: Difference between revisions
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'''SH3-Guanylate Kinase Module from PSD-95''' | '''SH3-Guanylate Kinase Module from PSD-95''' | ||
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[[Category: Olsen, O.]] | [[Category: Olsen, O.]] | ||
[[Category: Prehoda, K E.]] | [[Category: Prehoda, K E.]] | ||
[[Category: | [[Category: Protein-protein interaction]] | ||
[[Category: | [[Category: Scaffold]] | ||
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Revision as of 22:49, 2 May 2008
SH3-Guanylate Kinase Module from PSD-95
OverviewOverview
Membrane-associated guanylate kinases (MAGUKs), such as PSD-95, are modular scaffolds that organize signaling complexes at synapses and other cell junctions. MAGUKs contain PDZ domains, which recruit signaling proteins, as well as a Src homology 3 (SH3) and a guanylate kinase-like (GK) domain, implicated in scaffold oligomerization. The crystal structure of the SH3-GK module from PSD-95 reveals that these domains form an integrated unit: the SH3 fold comprises noncontiguous sequence elements divided by a hinge region and the GK domain. These elements compose two subdomains that can assemble in either an intra- or intermolecular fashion to complete the SH3 fold. We propose a model for MAGUK oligomerization in which complementary SH3 subdomains associate by 3D domain swapping. This model provides a possible mechanism for ligand regulation of oligomerization.
About this StructureAbout this Structure
1KJW is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
ReferenceReference
Structure of the SH3-guanylate kinase module from PSD-95 suggests a mechanism for regulated assembly of MAGUK scaffolding proteins., McGee AW, Dakoji SR, Olsen O, Bredt DS, Lim WA, Prehoda KE, Mol Cell. 2001 Dec;8(6):1291-301. PMID:11779504 Page seeded by OCA on Fri May 2 22:49:51 2008