4xeh: Difference between revisions

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 <StructureSection load='4xeh' size='340' side='right'caption='[[4xeh]], [[Resolution|resolution]] 1.39&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4xeh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ignaa Ignaa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XEH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XEH FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4xeh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ignisphaera_aggregans_DSM_17230 Ignisphaera aggregans DSM 17230]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XEH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XEH FirstGlance]. <br>
-</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ilvC, Igag_1561 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=583356 IGNAA])</td></tr>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xeh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xeh OCA], [https://pdbe.org/4xeh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xeh RCSB], [https://www.ebi.ac.uk/pdbsum/4xeh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xeh ProSAT]</span></td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ketol-acid_reductoisomerase Ketol-acid reductoisomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.86 1.1.1.86] </span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xeh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xeh OCA], [http://pdbe.org/4xeh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xeh RCSB], [http://www.ebi.ac.uk/pdbsum/4xeh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xeh ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/ILVC_IGNAA ILVC_IGNAA] Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH or NADH to yield (R)-2,3-dihydroxy-isovalerate.<ref>PMID:25172159</ref> <ref>PMID:26644020</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 19: / Line 19: @@
 ==See Also==
-*[[Ketol-acid reductoisomerase|Ketol-acid reductoisomerase]]
+*[[Ketol-acid reductoisomerase 3D structures|Ketol-acid reductoisomerase 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Ignaa]]
+[[Category: Ignisphaera aggregans DSM 17230]]
-[[Category: Ketol-acid reductoisomerase]]
 [[Category: Large Structures]]
-[[Category: Arnold, F H]]
+[[Category: Arnold FH]]
-[[Category: Brinkmann-Chen, S]]
+[[Category: Brinkmann-Chen S]]
-[[Category: Cahn, J K.B]]
+[[Category: Cahn JKB]]
-[[Category: Kari]]
-[[Category: Oxidoreductase]]
-[[Category: Rossmann fold]]