1kj2: Difference between revisions

Revision as of 22:48, 2 May 2008

Murine Alloreactive ScFv TCR-Peptide-MHC Class I Molecule Complex

OverviewOverview

The elongated complementary-determining region (CDR) 3beta found in the unliganded KB5-C20 TCR protrudes from the antigen binding site and prevents its docking onto the peptide/MHC (pMHC) surface according to a canonical diagonal orientation. We now present the crystal structure of a complex involving the KB5-C20 TCR and an octapeptide bound to the allogeneic H-2K(b) MHC class I molecule. This structure reveals how a tremendously large CDR3beta conformational change allows the KB5-C20 TCR to adapt to the rather constrained pMHC surface and achieve a diagonal docking mode. This extreme case of induced fit also shows that TCR plasticity is primarily restricted to CDR3 loops and does not propagate away from the antigen binding site.

About this StructureAbout this Structure

1KJ2 is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

ReferenceReference

A T cell receptor CDR3beta loop undergoes conformational changes of unprecedented magnitude upon binding to a peptide/MHC class I complex., Reiser JB, Gregoire C, Darnault C, Mosser T, Guimezanes A, Schmitt-Verhulst AM, Fontecilla-Camps JC, Mazza G, Malissen B, Housset D, Immunity. 2002 Mar;16(3):345-54. PMID:11911820 Page seeded by OCA on Fri May 2 22:48:24 2008

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OCA

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 [[Image:1kj2.gif|left|200px]]
- {{Structure
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-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kj2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kj2 OCA], [http://www.ebi.ac.uk/pdbsum/1kj2 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1kj2 RCSB]</span>
-}}
 '''Murine Alloreactive ScFv TCR-Peptide-MHC Class I Molecule Complex'''
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 [[Category: Reiser, J B.]]
 [[Category: Schmitt-Verhulst, A M.]]
-[[Category: allogeneic]]
+[[Category: Allogeneic]]
-[[Category: class i mhc]]
+[[Category: Class i mhc]]
-[[Category: h-2kb]]
+[[Category: H-2kb]]
-[[Category: t cell receptor]]
+[[Category: T cell receptor]]
-[[Category: tcr-pmhc complex]]
+[[Category: Tcr-pmhc complex]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 22:48:24 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:49:16 2008''