1khd: Difference between revisions

Revision as of 22:44, 2 May 2008

Crystal Structure Analysis of the anthranilate phosphoribosyltransferase from Erwinia carotovora at 1.9 resolution (current name, Pectobacterium carotovorum)

OverviewOverview

The structure of anthranilate phosphoribosyltransferase from the enterobacterium Pectobacterium carotovorum has been solved at 2.4 A in complex with Mn(2+)-pyrophosphate, and at 1.9 A without ligands. The enzyme structure has a novel phosphoribosyltransferase (PRT) fold and displays close homology to the structures of pyrimidine nucleoside phosphorylases. The enzyme is a homodimer with a monomer of 345 residues. Each monomer consists of two subdomains, alpha and alpha/beta, which form a cleft containing the active site. The nature of the active site is inferred from the trapped MnPPi complex and detailed knowledge of the active sites of nucleoside phosphorylases. With the anthranilate (An)PRT structure solved, the structures of all the enzymes required for tryptophan biosynthesis are now known.

About this StructureAbout this Structure

1KHD is a Single protein structure of sequence from Pectobacterium carotovorum. Full crystallographic information is available from OCA.

ReferenceReference

The crystal structure of anthranilate phosphoribosyltransferase from the enterobacterium Pectobacterium carotovorum., Kim C, Xuong NH, Edwards S, Madhusudan, Yee MC, Spraggon G, Mills SE, FEBS Lett. 2002 Jul 17;523(1-3):239-46. PMID:12123839 Page seeded by OCA on Fri May 2 22:44:56 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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 [[Image:1khd.jpg|left|200px]]
- {{Structure
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+The line below this paragraph, containing "STRUCTURE_1khd", creates the "Structure Box" on the page.
-|SITE=
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND=
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Anthranilate_phosphoribosyltransferase Anthranilate phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.18 2.4.2.18] </span>
+or leave the SCENE parameter empty for the default display.
-|GENE= trpD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=554 Pectobacterium carotovorum])
+-->
-|DOMAIN=
+{{STRUCTURE_1khd|  PDB=1khd  |  SCENE=  }}
-|RELATEDENTRY=[[1kgz|1KGZ]]
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1khd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1khd OCA], [http://www.ebi.ac.uk/pdbsum/1khd PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1khd RCSB]</span>
-}}
 '''Crystal Structure Analysis of the anthranilate phosphoribosyltransferase from Erwinia carotovora at 1.9 resolution (current name, Pectobacterium carotovorum)'''
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 [[Category: Xuong, N H.]]
 [[Category: Yee, M C.]]
-[[Category: nucleotide binding fold]]
+[[Category: Nucleotide binding fold]]
-[[Category: type 3 prt fold]]
+[[Category: Type 3 prt fold]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 22:44:56 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:48:37 2008''