Sandbox Reserved 1788: Difference between revisions
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=Overall Structure= | =Overall Structure= | ||
[[Image:Switches.png|500 px|right| thumb|'''Figure 2:'''Steric clashing of Switch I and II of GDP bound MRAS, in green, with SHOC2s surface, in magenta. GTP bound MRAS, in white, shows no steric clashing with SHOC2s surface.<div><font.]] | |||
== SHOC2 == | == SHOC2 == | ||
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Mutations affecting SMP complex formation and stability have been shown to increase or decrease MAPK signaling. Increased stability of the complex increases MAPK signaling while decreased stability decreases signaling. | Mutations affecting SMP complex formation and stability have been shown to increase or decrease MAPK signaling. Increased stability of the complex increases MAPK signaling while decreased stability decreases signaling. | ||
[[Image:Signal_cascade_small.jpg|800 px|thumb|center|'''Figure | [[Image:Signal_cascade_small.jpg|800 px|thumb|center|'''Figure 3:'''Signaling cascade is shown with SHOC2 in pink, PP1C in blue, and MRAs in white. ]] | ||
[[Image:Dephosphorylation.jpg|600 px|thumb|center|'''Figure | [[Image:Dephosphorylation.jpg|600 px|thumb|center|'''Figure 4:'''PP1C dephosphorylates RAF protein at serine 259 ]] | ||