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==Crystal structure of Saccharomyces cerevisiae OMP synthase in complex with PRP(CH2)P==
==Crystal structure of Saccharomyces cerevisiae OMP synthase in complex with PRP(CH2)P==
<StructureSection load='4wml' size='340' side='right' caption='[[4wml]], [[Resolution|resolution]] 1.73&Aring;' scene=''>
<StructureSection load='4wml' size='340' side='right'caption='[[4wml]], [[Resolution|resolution]] 1.73&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4wml]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WML OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WML FirstGlance]. <br>
<table><tr><td colspan='2'>[[4wml]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WML OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WML FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PPC:5-PHOSPHORIBOSYL-1-(BETA-METHYLENE)+PYROPHOSPHATE'>PPC</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PPC:5-PHOSPHORIBOSYL-1-(BETA-METHYLENE)+PYROPHOSPHATE'>PPC</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2pry|2pry]], [[2prz|2prz]], [[2ps1|2ps1]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wml FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wml OCA], [https://pdbe.org/4wml PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wml RCSB], [https://www.ebi.ac.uk/pdbsum/4wml PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wml ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">URA5, PYR5, YML106W, YM8339.13 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Orotate_phosphoribosyltransferase Orotate phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.10 2.4.2.10] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wml FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wml OCA], [http://pdbe.org/4wml PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4wml RCSB], [http://www.ebi.ac.uk/pdbsum/4wml PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4wml ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PYRE_YEAST PYRE_YEAST]] Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity).[HAMAP-Rule:MF_01208]  
[https://www.uniprot.org/uniprot/PYRE_YEAST PYRE_YEAST] Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity).[HAMAP-Rule:MF_01208]
 
==See Also==
*[[Phosphoribosyltransferase 3D structures|Phosphoribosyltransferase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Baker's yeast]]
[[Category: Large Structures]]
[[Category: Orotate phosphoribosyltransferase]]
[[Category: Saccharomyces cerevisiae S288C]]
[[Category: Bang, M B]]
[[Category: Bang MB]]
[[Category: Grubmeyer, C]]
[[Category: Grubmeyer C]]
[[Category: Hansen, M R]]
[[Category: Hansen MR]]
[[Category: Harris, P]]
[[Category: Harris P]]
[[Category: Molich, U]]
[[Category: Molich U]]
[[Category: Transferase]]

Revision as of 10:16, 7 April 2023

Crystal structure of Saccharomyces cerevisiae OMP synthase in complex with PRP(CH2)PCrystal structure of Saccharomyces cerevisiae OMP synthase in complex with PRP(CH2)P

Structural highlights

4wml is a 1 chain structure with sequence from Saccharomyces cerevisiae S288C. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PYRE_YEAST Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity).[HAMAP-Rule:MF_01208]

See Also

4wml, resolution 1.73Å

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