1kfr: Difference between revisions

Revision as of 22:41, 2 May 2008

Structural plasticity in the eight-helix fold of a trematode hemoglobin

OverviewOverview

The three-dimensional structure of recombinant haemoglobin from the trematode Paramphistomum epiclitum, displaying the highest oxygen affinity so far observed for (non)vertebrate haemoglobins, has previously been determined at 1.17 A resolution (orthorhombic space group P2(1)2(1)2(1)). In the present communication, the three-dimensional structure of wild-type P. epiclitum haemoglobin is reported at 1.85 A resolution in a monoclinic crystal form (R factor = 16.1%, R(free) = 22.0%). Comparison of P. epiclitum (recombinant versus wild-type ferric Hb) structures in the two crystal forms shows structural differences in the haem proximal and distal sites which have not been reported for other known haemoglobin structures previously.

About this StructureAbout this Structure

1KFR is a Single protein structure of sequence from Paramphistomum epiclitum. Full crystallographic information is available from OCA.

ReferenceReference

Structural plasticity in the eight-helix fold of a trematode haemoglobin., Milani M, Pesce A, Dewilde S, Ascenzi P, Moens L, Bolognesi M, Acta Crystallogr D Biol Crystallogr. 2002 Apr;58(Pt 4):719-22. Epub 2002, Mar 22. PMID:11914507 Page seeded by OCA on Fri May 2 22:41:30 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
 [[Image:1kfr.jpg|left|200px]]
- {{Structure
+<!--
-|PDB= 1kfr |SIZE=350|CAPTION= <scene name='initialview01'>1kfr</scene>, resolution 1.85&Aring;
+The line below this paragraph, containing "STRUCTURE_1kfr", creates the "Structure Box" on the page.
-|SITE=
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY=
+or leave the SCENE parameter empty for the default display.
-|GENE=
+-->
-|DOMAIN=
+{{STRUCTURE_1kfr|  PDB=1kfr  |  SCENE=  }}
-|RELATEDENTRY=[[1h97|1H97]]
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kfr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kfr OCA], [http://www.ebi.ac.uk/pdbsum/1kfr PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1kfr RCSB]</span>
-}}
 '''Structural plasticity in the eight-helix fold of a trematode hemoglobin'''
@@ Line 31: / Line 28: @@
 [[Category: Moens, L.]]
 [[Category: Pesce, A.]]
-[[Category: hemoglobin]]
+[[Category: Hemoglobin]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 22:41:30 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:47:57 2008''