5keq: Difference between revisions
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<SX load='5keq' size='340' side='right' viewer='molstar' caption='[[5keq]], [[Resolution|resolution]] 4.30Å' scene=''> | <SX load='5keq' size='340' side='right' viewer='molstar' caption='[[5keq]], [[Resolution|resolution]] 4.30Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5keq]] is a 6 chain structure with sequence from [ | <table><tr><td colspan='2'>[[5keq]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_papillomavirus_type_16 Human papillomavirus type 16]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KEQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5KEQ FirstGlance]. <br> | ||
</td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5keq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5keq OCA], [https://pdbe.org/5keq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5keq RCSB], [https://www.ebi.ac.uk/pdbsum/5keq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5keq ProSAT]</span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/VL1_HPV16 VL1_HPV16] Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. Binds to heparan sulfate proteoglycans on cell surface of basal layer keratinocytes to provide initial virion attachment. This binding mediates a conformational change in the virus capsid that facilitates efficient infection. The virion enters the host cell via endocytosis. During virus trafficking, L1 protein dissociates from the viral DNA and the genomic DNA is released to the host nucleus. The virion assembly takes place within the cell nucleus. Encapsulates the genomic DNA together with protein L2.[HAMAP-Rule:MF_04002]<ref>PMID:12610160</ref> <ref>PMID:26289843</ref> <ref>PMID:8553535</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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==See Also== | ==See Also== | ||
*[[ | *[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</SX> | </SX> | ||
[[Category: | [[Category: Human papillomavirus type 16]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Ashley | [[Category: Ashley RE]] | ||
[[Category: Brendle | [[Category: Brendle SA]] | ||
[[Category: Bywaters | [[Category: Bywaters SM]] | ||
[[Category: Christensen | [[Category: Christensen ND]] | ||
[[Category: Conway | [[Category: Conway JF]] | ||
[[Category: Guan | [[Category: Guan J]] | ||
[[Category: Hafenstein | [[Category: Hafenstein S]] | ||
[[Category: Makhov | [[Category: Makhov AM]] | ||