7ul8: Difference between revisions
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==[T:Au+:T--pH 11] Metal-mediated DNA base pair in tensegrity triangle== | |||
<StructureSection load='7ul8' size='340' side='right'caption='[[7ul8]], [[Resolution|resolution]] 4.22Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7ul8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UL8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7UL8 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AU:GOLD+ION'>AU</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ul8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ul8 OCA], [https://pdbe.org/7ul8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ul8 RCSB], [https://www.ebi.ac.uk/pdbsum/7ul8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ul8 ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
DNA double helices containing metal-mediated DNA (mmDNA) base pairs have been constructed from Ag(+) and Hg(2+) ions between pyrimidine:pyrimidine pairs with the promise of nanoelectronics. Rational design of mmDNA nanomaterials has been impractical without a complete lexical and structural description. Here, we explore the programmability of structural DNA nanotechnology toward its founding mission of self-assembling a diffraction platform for biomolecular structure determination. We employed the tensegrity triangle to build a comprehensive structural library of mmDNA pairs via X-ray diffraction and elucidated generalized design rules for mmDNA construction. We uncovered two binding modes: N3-dominant, centrosymmetric pairs and major groove binders driven by 5-position ring modifications. Energy gap calculations showed additional levels in the lowest unoccupied molecular orbitals (LUMO) of mmDNA structures, rendering them attractive molecular electronic candidates. This article is protected by copyright. All rights reserved. | |||
Metal-Mediated DNA Nanotechnology in 3D: Structural Library by Templated Diffraction.,Vecchioni S, Lu B, Livernois W, Ohayon YP, Yoder JB, Yang CF, Woloszyn K, Bernfeld W, Anantram MP, Canary JW, Hendrickson WA, Rothschild LJ, Mao C, Wind SJ, Seeman NC, Sha R Adv Mater. 2023 Mar 20:e2201938. doi: 10.1002/adma.202201938. PMID:36939292<ref>PMID:36939292</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
<div class="pdbe-citations 7ul8" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Synthetic construct]] | |||
[[Category: Lu B]] | |||
[[Category: Ohayon YP]] | |||
[[Category: Seeman NC]] | |||
[[Category: Sha R]] | |||
[[Category: Vecchioni S]] | |||
Revision as of 09:22, 7 April 2023
[T:Au+:T--pH 11] Metal-mediated DNA base pair in tensegrity triangle[T:Au+:T--pH 11] Metal-mediated DNA base pair in tensegrity triangle
Structural highlights
Publication Abstract from PubMedDNA double helices containing metal-mediated DNA (mmDNA) base pairs have been constructed from Ag(+) and Hg(2+) ions between pyrimidine:pyrimidine pairs with the promise of nanoelectronics. Rational design of mmDNA nanomaterials has been impractical without a complete lexical and structural description. Here, we explore the programmability of structural DNA nanotechnology toward its founding mission of self-assembling a diffraction platform for biomolecular structure determination. We employed the tensegrity triangle to build a comprehensive structural library of mmDNA pairs via X-ray diffraction and elucidated generalized design rules for mmDNA construction. We uncovered two binding modes: N3-dominant, centrosymmetric pairs and major groove binders driven by 5-position ring modifications. Energy gap calculations showed additional levels in the lowest unoccupied molecular orbitals (LUMO) of mmDNA structures, rendering them attractive molecular electronic candidates. This article is protected by copyright. All rights reserved. Metal-Mediated DNA Nanotechnology in 3D: Structural Library by Templated Diffraction.,Vecchioni S, Lu B, Livernois W, Ohayon YP, Yoder JB, Yang CF, Woloszyn K, Bernfeld W, Anantram MP, Canary JW, Hendrickson WA, Rothschild LJ, Mao C, Wind SJ, Seeman NC, Sha R Adv Mater. 2023 Mar 20:e2201938. doi: 10.1002/adma.202201938. PMID:36939292[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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