8ing: Difference between revisions

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'''Unreleased structure'''


The entry 8ing is ON HOLD
==Structure of the ternary complex of lactoperoxidase with substrate nitric oxide (NO) and product nitrite ion (NO2) at 1.98 A resolution==
 
<StructureSection load='8ing' size='340' side='right'caption='[[8ing]], [[Resolution|resolution]] 1.98&Aring;' scene=''>
Authors: Ahmad, M.I., Viswanathan, V., Kumar, M., Singh, R.P., Singh, A.K., Sinha, M., Kaur, P., Sharma, P., Sharma, S., Singh, T.P.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8ing]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Capra_hircus Capra hircus]. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=7wcs 7wcs] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4ljj 4ljj]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8ING OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8ING FirstGlance]. <br>
Description: Structure of the ternary complex of lactoperoxidase with substrate nitric oxide (NO) and product nitrite ion (NO2) at 1.98 A resolution
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NO:NITRIC+OXIDE'>NO</scene>, <scene name='pdbligand=NO2:NITRITE+ION'>NO2</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene>, <scene name='pdbligand=OSM:1-(OXIDOSULFANYL)METHANAMINE'>OSM</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ing FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ing OCA], [https://pdbe.org/8ing PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ing RCSB], [https://www.ebi.ac.uk/pdbsum/8ing PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ing ProSAT]</span></td></tr>
[[Category: Sinha, M]]
</table>
[[Category: Viswanathan, V]]
== Function ==
[[Category: Sharma, S]]
[https://www.uniprot.org/uniprot/PERL_CAPHI PERL_CAPHI] Antimicrobial agent which utilizes hydrogen peroxide and thiocyanate (SCN) to generate the antimicrobial substance hypothiocyanous acid (HOSCN) (PubMed:10894086). May protect the udder from infection and promote growth in newborns. Inhibits growth of several fungi including A.niger, Trichoderma species, C.cassicola, P.meadii and C.salmonicolor (PubMed:10894086). Does not have anti-fungal activity towards C.albicans and Pythium species (PubMed:10894086). Inhibits growth of several Gram-positive bacteria including some Staphylococcus species and Gram-negative bacteria including E.coli, P.aeruginosa and some Salmonella species (PubMed:10894086).<ref>PMID:10894086</ref>
[[Category: Sharma, P]]
== References ==
[[Category: Singh, R.P]]
<references/>
[[Category: Ahmad, M.I]]
__TOC__
[[Category: Singh, T.P]]
</StructureSection>
[[Category: Singh, A.K]]
[[Category: Capra hircus]]
[[Category: Kaur, P]]
[[Category: Large Structures]]
[[Category: Kumar, M]]
[[Category: Ahmad MI]]
[[Category: Kaur P]]
[[Category: Kumar M]]
[[Category: Sharma P]]
[[Category: Sharma S]]
[[Category: Singh AK]]
[[Category: Singh RP]]
[[Category: Singh TP]]
[[Category: Sinha M]]
[[Category: Viswanathan V]]

Latest revision as of 09:20, 7 April 2023

Structure of the ternary complex of lactoperoxidase with substrate nitric oxide (NO) and product nitrite ion (NO2) at 1.98 A resolutionStructure of the ternary complex of lactoperoxidase with substrate nitric oxide (NO) and product nitrite ion (NO2) at 1.98 A resolution

Structural highlights

8ing is a 1 chain structure with sequence from Capra hircus. This structure supersedes the now removed PDB entries 7wcs and 4ljj. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, , , , , , , , , , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PERL_CAPHI Antimicrobial agent which utilizes hydrogen peroxide and thiocyanate (SCN) to generate the antimicrobial substance hypothiocyanous acid (HOSCN) (PubMed:10894086). May protect the udder from infection and promote growth in newborns. Inhibits growth of several fungi including A.niger, Trichoderma species, C.cassicola, P.meadii and C.salmonicolor (PubMed:10894086). Does not have anti-fungal activity towards C.albicans and Pythium species (PubMed:10894086). Inhibits growth of several Gram-positive bacteria including some Staphylococcus species and Gram-negative bacteria including E.coli, P.aeruginosa and some Salmonella species (PubMed:10894086).[1]

References

  1. ↑ Benoy MJ, Essy AK, Sreekumar B, Haridas M. Thiocyanate mediated antifungal and antibacterial property of goat milk lactoperoxidase. Life Sci. 2000;66(25):2433-9. doi: 10.1016/s0024-3205(00)80003-x. PMID:10894086 doi:http://dx.doi.org/10.1016/s0024-3205(00)80003-x

8ing, resolution 1.98Å

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