4uis: Difference between revisions

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OCA

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 <SX load='4uis' size='340' side='right' viewer='molstar' caption='[[4uis]], [[Resolution|resolution]] 4.40&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4uis]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UIS OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=4UIS FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4uis]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UIS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UIS FirstGlance]. <br>
-</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4uis FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uis OCA], [https://pdbe.org/4uis PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4uis RCSB], [https://www.ebi.ac.uk/pdbsum/4uis PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4uis ProSAT]</span></td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=4uis FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uis OCA], [http://pdbe.org/4uis PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4uis RCSB], [http://www.ebi.ac.uk/pdbsum/4uis PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4uis ProSAT]</span></td></tr>
 </table>
+== Disease ==
+[https://www.uniprot.org/uniprot/NICA_HUMAN NICA_HUMAN] Hidradenitis suppurativa. The disease is caused by mutations affecting the gene represented in this entry.
+== Function ==
+[https://www.uniprot.org/uniprot/NICA_HUMAN NICA_HUMAN] Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex.
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 19: / Line 21: @@
 ==See Also==
-*[[Gamma secretase complex|Gamma secretase complex]]
+*[[Gamma secretase|Gamma secretase]]
 *[[Lysozyme 3D structures|Lysozyme 3D structures]]
 == References ==
@@ Line 25: / Line 27: @@
 __TOC__
 </SX>
-[[Category: Human]]
+[[Category: Homo sapiens]]
 [[Category: Large Structures]]
-[[Category: Lysozyme]]
+[[Category: Li X]]
-[[Category: Li, X]]
+[[Category: Shi Y]]
-[[Category: Shi, Y]]
+[[Category: Sun L]]
-[[Category: Sun, L]]
+[[Category: Wu S]]
-[[Category: Wu, S]]
+[[Category: Xie T]]
-[[Category: Xie, T]]
+[[Category: Yan C]]
-[[Category: Yan, C]]
+[[Category: Yang G]]
-[[Category: Yang, G]]
+[[Category: Zhao L]]
-[[Category: Zhao, L]]
+[[Category: Zhao Y]]
-[[Category: Zhao, Y]]
+[[Category: Zhou R]]
-[[Category: Zhou, R]]
+[[Category: Zhou X]]
-[[Category: Zhou, X]]
-[[Category: Gamma-secretase]]
-[[Category: Hydrolase]]