4tsk: Difference between revisions
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==Ketol-acid reductoisomerase from Alicyclobacillus acidocaldarius== | ==Ketol-acid reductoisomerase from Alicyclobacillus acidocaldarius== | ||
<StructureSection load='4tsk' size='340' side='right' caption='[[4tsk]], [[Resolution|resolution]] 2.50Å' scene=''> | <StructureSection load='4tsk' size='340' side='right'caption='[[4tsk]], [[Resolution|resolution]] 2.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4tsk]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4tsk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Alicyclobacillus_acidocaldarius_subsp._acidocaldarius_DSM_446 Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TSK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TSK FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4tsk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tsk OCA], [https://pdbe.org/4tsk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4tsk RCSB], [https://www.ebi.ac.uk/pdbsum/4tsk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4tsk ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/ILVC_ALIAD ILVC_ALIAD] Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.[HAMAP-Rule:MF_00435]<ref>PMID:25849365</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 18: | Line 18: | ||
</div> | </div> | ||
<div class="pdbe-citations 4tsk" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 4tsk" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Ketol-acid reductoisomerase 3D structures|Ketol-acid reductoisomerase 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Arnold | [[Category: Arnold FH]] | ||
[[Category: Brinkmann-Chen | [[Category: Brinkmann-Chen S]] | ||
[[Category: Cahn | [[Category: Cahn JKB]] | ||