4rs1: Difference between revisions

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 ==Crystal structure of receptor-cytokine complex==
-<StructureSection load='4rs1' size='340' side='right' caption='[[4rs1]], [[Resolution|resolution]] 2.68&Aring;' scene=''>
+<StructureSection load='4rs1' size='340' side='right'caption='[[4rs1]], [[Resolution|resolution]] 2.68&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4rs1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RS1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RS1 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4rs1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RS1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RS1 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CSF2R, CSF2RA, CSF2RY ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), CSF2, GMCSF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rs1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rs1 OCA], [https://pdbe.org/4rs1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rs1 RCSB], [https://www.ebi.ac.uk/pdbsum/4rs1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rs1 ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rs1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rs1 OCA], [http://pdbe.org/4rs1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rs1 RCSB], [http://www.ebi.ac.uk/pdbsum/4rs1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4rs1 ProSAT]</span></td></tr>
 </table>
 == Disease ==
-[[http://www.uniprot.org/uniprot/CSF2R_HUMAN CSF2R_HUMAN]] Defects in CSF2RA are the cause of pulmonary surfactant metabolism dysfunction type 4 (SMDP4) [MIM:[http://omim.org/entry/300770 300770]]. A rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress.<ref>PMID:18955567</ref> <ref>PMID:18955570</ref>
+[https://www.uniprot.org/uniprot/CSF2R_HUMAN CSF2R_HUMAN] Defects in CSF2RA are the cause of pulmonary surfactant metabolism dysfunction type 4 (SMDP4) [MIM:[https://omim.org/entry/300770 300770]. A rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress.<ref>PMID:18955567</ref> <ref>PMID:18955570</ref>
 == Function ==
-[[http://www.uniprot.org/uniprot/CSF2R_HUMAN CSF2R_HUMAN]] Low affinity receptor for granulocyte-macrophage colony-stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells. [[http://www.uniprot.org/uniprot/CSF2_HUMAN CSF2_HUMAN]] Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.
+[https://www.uniprot.org/uniprot/CSF2R_HUMAN CSF2R_HUMAN] Low affinity receptor for granulocyte-macrophage colony-stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells.
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 21: / Line 20: @@
 </div>
 <div class="pdbe-citations 4rs1" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Colony-stimulating factor 3D structures|Colony-stimulating factor 3D structures]]
+*[[Colony-stimulating factor receptor 3D structures|Colony-stimulating factor receptor 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
-[[Category: Broughton, S E]]
+[[Category: Large Structures]]
-[[Category: Dhagat, U]]
+[[Category: Broughton SE]]
-[[Category: Parker, M W]]
+[[Category: Dhagat U]]
-[[Category: Cytokine]]
+[[Category: Parker MW]]
-[[Category: Cytokine receptor-cytokine complex]]
-[[Category: Receptor]]