4rob: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
← Older editNewer edit →
No edit summary
No edit summary
Line 1: Line 1:


==2.8A resolution structure of SRPN2 (K198C) from Anopheles gambiae==
==2.8A resolution structure of SRPN2 (K198C) from Anopheles gambiae==
<StructureSection load='4rob' size='340' side='right' caption='[[4rob]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
<StructureSection load='4rob' size='340' side='right'caption='[[4rob]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4rob]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Anoga Anoga]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ROB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ROB FirstGlance]. <br>
<table><tr><td colspan='2'>[[4rob]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Anopheles_gambiae Anopheles gambiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ROB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ROB FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ro9|4ro9]], [[4roa|4roa]]</td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rob FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rob OCA], [https://pdbe.org/4rob PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rob RCSB], [https://www.ebi.ac.uk/pdbsum/4rob PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rob ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SRPN2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7165 ANOGA])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rob FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rob OCA], [http://pdbe.org/4rob PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rob RCSB], [http://www.ebi.ac.uk/pdbsum/4rob PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4rob ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SP2_ANOGA SP2_ANOGA] Serine protease inhibitor that functions in the melanization-mediated immune response (PubMed:16113656, PubMed:20953892, PubMed:33520733, PubMed:33045027, PubMed:21465556, PubMed:25525260). By preventing the activation of phenoloxidases through the inhibiting of serine proteases CLIPB9 and CLIPB10, negatively regulates melanization in the hemolymph (PubMed:16113656, PubMed:20953892, PubMed:33520733, PubMed:33045027, PubMed:21465556, PubMed:25525260). By preventing melanization, has a detrimental role during P.berghei parasite mediated-infection and invasion of the mosquito midgut (PubMed:16113656).<ref>PMID:16113656</ref> <ref>PMID:20953892</ref> <ref>PMID:21465556</ref> <ref>PMID:25525260</ref> <ref>PMID:33045027</ref> <ref>PMID:33520733</ref>
==See Also==
*[[Serpin 3D structures|Serpin 3D structures]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Anoga]]
[[Category: Anopheles gambiae]]
[[Category: An, C]]
[[Category: Large Structures]]
[[Category: Battaile, K P]]
[[Category: An C]]
[[Category: Lovell, S]]
[[Category: Battaile KP]]
[[Category: Meekins, D A]]
[[Category: Lovell S]]
[[Category: Michel, K]]
[[Category: Meekins DA]]
[[Category: Zhang, X]]
[[Category: Michel K]]
[[Category: Hydrolase inhibitor]]
[[Category: Zhang X]]
[[Category: Insect immunity]]
[[Category: Serine protease inhibitor]]
[[Category: Serpin]]

Revision as of 11:22, 8 March 2023

2.8A resolution structure of SRPN2 (K198C) from Anopheles gambiae2.8A resolution structure of SRPN2 (K198C) from Anopheles gambiae

Structural highlights

4rob is a 3 chain structure with sequence from Anopheles gambiae. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

SP2_ANOGA Serine protease inhibitor that functions in the melanization-mediated immune response (PubMed:16113656, PubMed:20953892, PubMed:33520733, PubMed:33045027, PubMed:21465556, PubMed:25525260). By preventing the activation of phenoloxidases through the inhibiting of serine proteases CLIPB9 and CLIPB10, negatively regulates melanization in the hemolymph (PubMed:16113656, PubMed:20953892, PubMed:33520733, PubMed:33045027, PubMed:21465556, PubMed:25525260). By preventing melanization, has a detrimental role during P.berghei parasite mediated-infection and invasion of the mosquito midgut (PubMed:16113656).[1] [2] [3] [4] [5] [6]

See Also

References

  1. ↑ Michel K, Budd A, Pinto S, Gibson TJ, Kafatos FC. Anopheles gambiae SRPN2 facilitates midgut invasion by the malaria parasite Plasmodium berghei. EMBO Rep. 2005 Sep;6(9):891-7. PMID:16113656 doi:10.1038/sj.embor.7400478
  2. ↑ An C, Budd A, Kanost MR, Michel K. Characterization of a regulatory unit that controls melanization and affects longevity of mosquitoes. Cell Mol Life Sci. 2011 Jun;68(11):1929-39. PMID:20953892 doi:10.1007/s00018-010-0543-z
  3. ↑ An C, Lovell S, Kanost MR, Battaile KP, Michel K. Crystal structure of native Anopheles gambiae serpin-2, a negative regulator of melanization in mosquitoes. Proteins. 2011 Feb 3. doi: 10.1002/prot.23002. PMID:21465556 doi:10.1002/prot.23002
  4. ↑ Zhang X, Meekins DA, An C, Zolkiewski M, Battaile KP, Kanost MR, Lovell S, Michel K. Structural and Inhibitory Effects of Hinge Loop Mutagenesis in Serpin-2 from the Malaria Vector Anopheles gambiae. J Biol Chem. 2015 Jan 30;290(5):2946-56. doi: 10.1074/jbc.M114.625665. Epub 2014 , Dec 17. PMID:25525260 doi:http://dx.doi.org/10.1074/jbc.M114.625665
  5. ↑ Sousa GL, Bishnoi R, Baxter RHG, Povelones M. The CLIP-domain serine protease CLIPC9 regulates melanization downstream of SPCLIP1, CLIPA8, and CLIPA28 in the malaria vector Anopheles gambiae. PLoS Pathog. 2020 Oct 12;16(10):e1008985. PMID:33045027 doi:10.1371/journal.ppat.1008985
  6. ↑ Zhang X, Li M, El Moussawi L, Saab S, Zhang S, Osta MA, Michel K. CLIPB10 is a Terminal Protease in the Regulatory Network That Controls Melanization in the African Malaria Mosquito Anopheles gambiae. Front Cell Infect Microbiol. 2021 Jan 15;10:585986. PMID:33520733 doi:10.3389/fcimb.2020.585986

4rob, resolution 2.80Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=4rob&oldid=3730488"