4ra2: Difference between revisions
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<StructureSection load='4ra2' size='340' side='right'caption='[[4ra2]], [[Resolution|resolution]] 1.94Å' scene=''> | <StructureSection load='4ra2' size='340' side='right'caption='[[4ra2]], [[Resolution|resolution]] 1.94Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4ra2]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4ra2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RA2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RA2 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ra2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ra2 OCA], [https://pdbe.org/4ra2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ra2 RCSB], [https://www.ebi.ac.uk/pdbsum/4ra2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ra2 ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/PPM1A_HUMAN PPM1A_HUMAN] Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling.<ref>PMID:16751101</ref> | ||
==See Also== | ==See Also== | ||
*[[Protein phosphatase 3D structures|Protein phosphatase 3D structures]] | *[[Protein phosphatase 3D structures|Protein phosphatase 3D structures]] | ||
== References == | == References == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Liu HD]] | |||
[[Category: Liu | [[Category: Meng FG]] | ||
[[Category: Meng | [[Category: Pan C]] | ||
[[Category: Pan | [[Category: Sun JP]] | ||
[[Category: Sun | [[Category: Tang JY]] | ||
[[Category: Tang | [[Category: Wang HA]] | ||
[[Category: Wang | [[Category: Wang WB]] | ||
[[Category: Wang | [[Category: Xiao P]] | ||
[[Category: Xiao | [[Category: Xu YF]] | ||
[[Category: Xu | [[Category: Yu X]] | ||
[[Category: Yu | |||