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==Crystal structure of Rhodostomin KKKRT mutant==
==Crystal structure of Rhodostomin KKKRT mutant==
<StructureSection load='4r5r' size='340' side='right' caption='[[4r5r]], [[Resolution|resolution]] 0.96&Aring;' scene=''>
<StructureSection load='4r5r' size='340' side='right'caption='[[4r5r]], [[Resolution|resolution]] 0.96&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4r5r]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Agkistrodon_rhodostoma Agkistrodon rhodostoma]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R5R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4R5R FirstGlance]. <br>
<table><tr><td colspan='2'>[[4r5r]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Calloselasma_rhodostoma Calloselasma rhodostoma]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R5R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4R5R FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4r5u|4r5u]]</td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4r5r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r5r OCA], [https://pdbe.org/4r5r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4r5r RCSB], [https://www.ebi.ac.uk/pdbsum/4r5r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4r5r ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RHOD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=8717 Agkistrodon rhodostoma])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4r5r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r5r OCA], [http://pdbe.org/4r5r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4r5r RCSB], [http://www.ebi.ac.uk/pdbsum/4r5r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4r5r ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/VM2RH_CALRH VM2RH_CALRH]] Metalloproteinase rhodostoxin: snake venom metalloproteinase that impairs hemostasis in the envenomed animal (By similarity).  Disintegrin rhodostomin: inhibit platelet aggregation induced by ADP, thrombin, platelet-activating factor and collagen. Acts by inhibiting fibrinogen interaction with platelet receptors GPIIb/GPIIIa (ITGA2B/ITGB3).  
[https://www.uniprot.org/uniprot/VM2RH_CALRH VM2RH_CALRH] Metalloproteinase rhodostoxin: snake venom metalloproteinase that impairs hemostasis in the envenomed animal (By similarity).  Disintegrin rhodostomin: inhibit platelet aggregation induced by ADP, thrombin, platelet-activating factor and collagen. Acts by inhibiting fibrinogen interaction with platelet receptors GPIIb/GPIIIa (ITGA2B/ITGB3).
 
==See Also==
*[[Disintegrin|Disintegrin]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Agkistrodon rhodostoma]]
[[Category: Calloselasma rhodostoma]]
[[Category: Chang, Y T]]
[[Category: Large Structures]]
[[Category: Chuang, W J]]
[[Category: Chang YT]]
[[Category: Huang, C H]]
[[Category: Chuang WJ]]
[[Category: Jeng, W Y]]
[[Category: Huang CH]]
[[Category: Shiu, J H]]
[[Category: Jeng WY]]
[[Category: Disintegrin]]
[[Category: Shiu JH]]
[[Category: Integrin]]
[[Category: Linker region]]
[[Category: Rgd motif]]
[[Category: Rhodostomin]]
[[Category: Toxin]]

Revision as of 09:41, 2 March 2023

Crystal structure of Rhodostomin KKKRT mutantCrystal structure of Rhodostomin KKKRT mutant

Structural highlights

4r5r is a 2 chain structure with sequence from Calloselasma rhodostoma. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

VM2RH_CALRH Metalloproteinase rhodostoxin: snake venom metalloproteinase that impairs hemostasis in the envenomed animal (By similarity). Disintegrin rhodostomin: inhibit platelet aggregation induced by ADP, thrombin, platelet-activating factor and collagen. Acts by inhibiting fibrinogen interaction with platelet receptors GPIIb/GPIIIa (ITGA2B/ITGB3).

See Also

4r5r, resolution 0.96Å

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