8fg5: Difference between revisions

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-'''Unreleased structure'''
-The entry 8fg5 is ON HOLD
+==Apo mouse acidic mammalian chitinase, catalytic domain at 100 K==
+<StructureSection load='8fg5' size='340' side='right'caption='[[8fg5]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
-Authors: Diaz, R.E., Correy, G.J., Young, I.D., Thompson, M.C., Fraser, J.S.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8fg5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8FG5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8FG5 FirstGlance]. <br>
-Description: Apo mouse acidic mammalian chitinase, catalytic domain at 100 K
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8fg5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8fg5 OCA], [https://pdbe.org/8fg5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8fg5 RCSB], [https://www.ebi.ac.uk/pdbsum/8fg5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8fg5 ProSAT]</span></td></tr>
-[[Category: Diaz, R.E]]
+</table>
-[[Category: Thompson, M.C]]
+== Function ==
-[[Category: Correy, G.J]]
+[https://www.uniprot.org/uniprot/CHIA_MOUSE CHIA_MOUSE] Degrades chitin and chitotriose. May participate in the defense against nematodes, fungi and other pathogens. Plays a role in T-helper cell type 2 (Th2) immune response. Contributes to the response to IL-13 and inflammation in response to IL-13. Stimulates chemokine production by pulmonary epithelial cells. Protects lung epithelial cells against apoptosis and promotes phosphorylation of AKT1. Its function in the inflammatory response and in protecting cells against apoptosis is inhibited by allosamidin, suggesting that the function of this protein depends on carbohydrate binding. Presence in saliva and gastric juice suggests a function as a digestive enzyme.<ref>PMID:11085997</ref> <ref>PMID:12133911</ref> <ref>PMID:15192232</ref> <ref>PMID:19076793</ref>
-[[Category: Fraser, J.S]]
+== References ==
-[[Category: Young, I.D]]
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Mus musculus]]
+[[Category: Correy GJ]]
+[[Category: Diaz RE]]
+[[Category: Fraser JS]]
+[[Category: Thompson MC]]
+[[Category: Young ID]]