4qqe: Difference between revisions

<table><tr><td colspan='2'>[[4qqe]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QQE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QQE FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=37F:N-[2-(4-METHYLPIPERAZIN-1-YL)-5-(QUINOLIN-3-YL)PHENYL]-6-OXO-4-(TRIFLUOROMETHYL)-1,6-DIHYDROPYRIDINE-3-CARBOXAMIDE'>37F</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qqe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qqe OCA], [https://pdbe.org/4qqe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qqe RCSB], [https://www.ebi.ac.uk/pdbsum/4qqe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qqe ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/WDR5_HUMAN WDR5_HUMAN] Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.<ref>PMID:19556245</ref> <ref>PMID:19103755</ref> <ref>PMID:20018852</ref> <ref>PMID:16600877</ref> <ref>PMID:16829960</ref>  

*[[WD-repeat protein 3D structures|WD-repeat protein 3D structures]]

[[Category: Homo sapiens]]

[[Category: Al-Awar R]]

[[Category: Arrowsmith CH]]

[[Category: Bountra C]]

[[Category: Brown PJ]]

[[Category: Dombrovski L]]

[[Category: Dong A]]

[[Category: Edwards AM]]

[[Category: Getlik M]]

[[Category: Poda G]]

[[Category: Schapira M]]

[[Category: Senisterra G]]

[[Category: Smil D]]

[[Category: Vedadi M]]

[[Category: Wernimont A]]

[[Category: Wu H]]