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==The C-terminal Region of Disintegrin Modulate its 3D Conformation and Cooperate with RGD Loop in Regulating Recognitions of Integrins== | ==The C-terminal Region of Disintegrin Modulate its 3D Conformation and Cooperate with RGD Loop in Regulating Recognitions of Integrins== | ||
<StructureSection load='2m75' size='340' side='right'caption='[[2m75 | <StructureSection load='2m75' size='340' side='right'caption='[[2m75]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2m75]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2m75]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Calloselasma_rhodostoma Calloselasma rhodostoma]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M75 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M75 FirstGlance]. <br> | ||
</td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m75 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m75 OCA], [https://pdbe.org/2m75 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m75 RCSB], [https://www.ebi.ac.uk/pdbsum/2m75 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m75 ProSAT]</span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m75 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m75 OCA], [https://pdbe.org/2m75 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m75 RCSB], [https://www.ebi.ac.uk/pdbsum/2m75 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m75 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/VM2RH_CALRH VM2RH_CALRH] Metalloproteinase rhodostoxin: snake venom metalloproteinase that impairs hemostasis in the envenomed animal (By similarity). Disintegrin rhodostomin: inhibit platelet aggregation induced by ADP, thrombin, platelet-activating factor and collagen. Acts by inhibiting fibrinogen interaction with platelet receptors GPIIb/GPIIIa (ITGA2B/ITGB3). | |||
==See Also== | |||
*[[Disintegrin|Disintegrin]] | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Calloselasma rhodostoma]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Chang | [[Category: Chang Y]] | ||
[[Category: Chuang | [[Category: Chuang W]] | ||
[[Category: Shiu | [[Category: Shiu J]] | ||
Revision as of 16:32, 22 February 2023
The C-terminal Region of Disintegrin Modulate its 3D Conformation and Cooperate with RGD Loop in Regulating Recognitions of IntegrinsThe C-terminal Region of Disintegrin Modulate its 3D Conformation and Cooperate with RGD Loop in Regulating Recognitions of Integrins
Structural highlights
FunctionVM2RH_CALRH Metalloproteinase rhodostoxin: snake venom metalloproteinase that impairs hemostasis in the envenomed animal (By similarity). Disintegrin rhodostomin: inhibit platelet aggregation induced by ADP, thrombin, platelet-activating factor and collagen. Acts by inhibiting fibrinogen interaction with platelet receptors GPIIb/GPIIIa (ITGA2B/ITGB3). See Also |
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