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==Solution NMR Structure of Homeobox 2 Domain from Human ZHX1 repressor, Northeast Structural Genomics Consortium (NESG) Target HR7907F==
==Solution NMR Structure of Homeobox 2 Domain from Human ZHX1 repressor, Northeast Structural Genomics Consortium (NESG) Target HR7907F==
<StructureSection load='2ly9' size='340' side='right'caption='[[2ly9]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2ly9' size='340' side='right'caption='[[2ly9]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2ly9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LY9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LY9 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2ly9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LY9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LY9 FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ZHX1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ly9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ly9 OCA], [https://pdbe.org/2ly9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ly9 RCSB], [https://www.ebi.ac.uk/pdbsum/2ly9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ly9 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ly9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ly9 OCA], [https://pdbe.org/2ly9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ly9 RCSB], [https://www.ebi.ac.uk/pdbsum/2ly9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ly9 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/ZHX1_HUMAN ZHX1_HUMAN]] Acts as a transcriptional repressor. Increases DNMT3B-mediated repressive transcriptional activity when DNMT3B is tethered to DNA. May link molecule between DNMT3B and other co-repressor proteins.<ref>PMID:12237128</ref>
[https://www.uniprot.org/uniprot/ZHX1_HUMAN ZHX1_HUMAN] Acts as a transcriptional repressor. Increases DNMT3B-mediated repressive transcriptional activity when DNMT3B is tethered to DNA. May link molecule between DNMT3B and other co-repressor proteins.<ref>PMID:12237128</ref>  
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Acton, T B]]
[[Category: Acton TB]]
[[Category: Eletsky, A]]
[[Category: Eletsky A]]
[[Category: Everett, J K]]
[[Category: Everett JK]]
[[Category: Janjua, H]]
[[Category: Janjua H]]
[[Category: Kohan, E]]
[[Category: Kohan E]]
[[Category: Lee, D]]
[[Category: Lee D]]
[[Category: Mills, J L]]
[[Category: Mills JL]]
[[Category: Montelione, G T]]
[[Category: Montelione GT]]
[[Category: Structural genomic]]
[[Category: Pulavarti SVSRK]]
[[Category: Pulavarti, S V.S R.K]]
[[Category: Szyperski T]]
[[Category: Szyperski, T]]
[[Category: Xiao R]]
[[Category: Xiao, R]]
[[Category: Xu X]]
[[Category: Xu, X]]
[[Category: PSI, Protein structure initiative]]
[[Category: Psi-biology]]
[[Category: Transcription]]

Revision as of 16:19, 22 February 2023

Solution NMR Structure of Homeobox 2 Domain from Human ZHX1 repressor, Northeast Structural Genomics Consortium (NESG) Target HR7907FSolution NMR Structure of Homeobox 2 Domain from Human ZHX1 repressor, Northeast Structural Genomics Consortium (NESG) Target HR7907F

Structural highlights

2ly9 is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ZHX1_HUMAN Acts as a transcriptional repressor. Increases DNMT3B-mediated repressive transcriptional activity when DNMT3B is tethered to DNA. May link molecule between DNMT3B and other co-repressor proteins.[1]

References

  1. ↑ Yamada K, Kawata H, Matsuura K, Shou Z, Hirano S, Mizutani T, Yazawa T, Yoshino M, Sekiguchi T, Kajitani T, Miyamoto K. Functional analysis and the molecular dissection of zinc-fingers and homeoboxes 1 (ZHX1). Biochem Biophys Res Commun. 2002 Sep 20;297(2):368-74. PMID:12237128
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