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==Solution structure of the SANT2 domain of the human nuclear receptor corepressor 2 (NCoR2), Northeast Structural Genomics Consortium (NESG) target ID HR4636E== | ==Solution structure of the SANT2 domain of the human nuclear receptor corepressor 2 (NCoR2), Northeast Structural Genomics Consortium (NESG) target ID HR4636E== | ||
<StructureSection load='2ltp' size='340' side='right'caption='[[2ltp | <StructureSection load='2ltp' size='340' side='right'caption='[[2ltp]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2ltp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2ltp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LTP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LTP FirstGlance]. <br> | ||
</td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ltp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ltp OCA], [https://pdbe.org/2ltp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ltp RCSB], [https://www.ebi.ac.uk/pdbsum/2ltp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ltp ProSAT]</span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ltp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ltp OCA], [https://pdbe.org/2ltp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ltp RCSB], [https://www.ebi.ac.uk/pdbsum/2ltp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ltp ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/NCOR2_HUMAN NCOR2_HUMAN] Transcriptional corepressor of NR4A2/NURR1 and acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state (By similarity). Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 5 have different affinities for different nuclear receptors. | |||
==See Also== | ==See Also== | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Arrowsmith | [[Category: Arrowsmith C]] | ||
[[Category: Bellanda | [[Category: Bellanda M]] | ||
[[Category: Garcia | [[Category: Garcia M]] | ||
[[Category: Houliston | [[Category: Houliston S]] | ||
[[Category: Lemak | [[Category: Lemak A]] | ||
[[Category: Min | [[Category: Min J]] | ||
[[Category: Montecchio | [[Category: Montecchio M]] | ||
[[Category: Montelione | [[Category: Montelione GT]] | ||
[[Category: Xu C]] | |||
[[Category: Xu | [[Category: Yee A]] | ||
[[Category: Yee | |||
Revision as of 16:10, 22 February 2023
Solution structure of the SANT2 domain of the human nuclear receptor corepressor 2 (NCoR2), Northeast Structural Genomics Consortium (NESG) target ID HR4636ESolution structure of the SANT2 domain of the human nuclear receptor corepressor 2 (NCoR2), Northeast Structural Genomics Consortium (NESG) target ID HR4636E
Structural highlights
FunctionNCOR2_HUMAN Transcriptional corepressor of NR4A2/NURR1 and acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state (By similarity). Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 5 have different affinities for different nuclear receptors. See Also |
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