8hcz: Difference between revisions

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'''Unreleased structure'''


The entry 8hcz is ON HOLD  until Paper Publication
==N-terminal domain structure of mycobacterium tuberculosis FadD23==
 
<StructureSection load='8hcz' size='340' side='right'caption='[[8hcz]], [[Resolution|resolution]] 1.48&Aring;' scene=''>
Authors:  
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8hcz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8HCZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8HCZ FirstGlance]. <br>
Description:  
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8hcz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8hcz OCA], [https://pdbe.org/8hcz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8hcz RCSB], [https://www.ebi.ac.uk/pdbsum/8hcz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8hcz ProSAT]</span></td></tr>
[[Category: Unreleased Structures]]
</table>
== Function ==
[https://www.uniprot.org/uniprot/FAA23_MYCTU FAA23_MYCTU] Catalyzes the activation of long-chain fatty acids as acyl-adenylates (acyl-AMP), which are then transferred to the multifunctional polyketide synthase (PKS) type III for further chain extension (Probable). Involved in the biosynthesis of sulfolipid 1 (SL-1) (PubMed:17389997, PubMed:17768256).<ref>PMID:17389997</ref> <ref>PMID:17768256</ref> <ref>PMID:17768256</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis H37Rv]]
[[Category: Liu X]]
[[Category: Rao ZH]]
[[Category: Yan MR]]
[[Category: Zhang W]]

Revision as of 13:30, 15 February 2023

N-terminal domain structure of mycobacterium tuberculosis FadD23N-terminal domain structure of mycobacterium tuberculosis FadD23

Structural highlights

8hcz is a 1 chain structure with sequence from Mycobacterium tuberculosis H37Rv. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

FAA23_MYCTU Catalyzes the activation of long-chain fatty acids as acyl-adenylates (acyl-AMP), which are then transferred to the multifunctional polyketide synthase (PKS) type III for further chain extension (Probable). Involved in the biosynthesis of sulfolipid 1 (SL-1) (PubMed:17389997, PubMed:17768256).[1] [2] [3]

References

  1. ↑ Gokhale RS, Saxena P, Chopra T, Mohanty D. Versatile polyketide enzymatic machinery for the biosynthesis of complex mycobacterial lipids. Nat Prod Rep. 2007 Apr;24(2):267-77. PMID:17389997 doi:10.1039/b616817p
  2. ↑ Lynett J, Stokes RW. Selection of transposon mutants of Mycobacterium tuberculosis with increased macrophage infectivity identifies fadD23 to be involved in sulfolipid production and association with macrophages. Microbiology (Reading). 2007 Sep;153(Pt 9):3133-3140. PMID:17768256 doi:10.1099/mic.0.2007/007864-0
  3. ↑ Lynett J, Stokes RW. Selection of transposon mutants of Mycobacterium tuberculosis with increased macrophage infectivity identifies fadD23 to be involved in sulfolipid production and association with macrophages. Microbiology (Reading). 2007 Sep;153(Pt 9):3133-3140. PMID:17768256 doi:10.1099/mic.0.2007/007864-0

8hcz, resolution 1.48Å

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