8fhq: Difference between revisions

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-'''Unreleased structure'''
-The entry 8fhq is ON HOLD  until Paper Publication
+==Cryo-EM structure of human NCC (class 3-2)==
+<StructureSection load='8fhq' size='340' side='right'caption='[[8fhq]], [[Resolution|resolution]] 2.81&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8fhq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8FHQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8FHQ FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=XZF:Polythiazide'>XZF</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8fhq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8fhq OCA], [https://pdbe.org/8fhq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8fhq RCSB], [https://www.ebi.ac.uk/pdbsum/8fhq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8fhq ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/S12A3_HUMAN S12A3_HUMAN] Gitelman syndrome. The disease is caused by variants affecting the gene represented in this entry.
+== Function ==
+[https://www.uniprot.org/uniprot/S12A3_HUMAN S12A3_HUMAN] Electroneutral sodium and chloride ion cotransporter. In kidney distal convoluted tubules, key mediator of sodium and chloride reabsorption (PubMed:21613606, PubMed:22009145). Receptor for the pro-inflammatory cytokine IL18. Contributes to IL18-induced cytokine production, including IFNG, IL6, IL18 and CCL2. May act either independently of IL18R1, or in a complex with IL18R1 (By similarity).[UniProtKB:P59158]<ref>PMID:21613606</ref> <ref>PMID:22009145</ref> [https://www.uniprot.org/uniprot/S12A2_DANRE S12A2_DANRE] Cation-chloride cotransporter which mediates the electroneutral transport of chloride, potassium and/or sodium ions across the membrane (PubMed:31367042). Plays a vital role in the regulation of ionic balance and cell volume (PubMed:31367042). Important for maintenance of endolymph volume in the otic vesicle, probably by regulating ion homeostasis (PubMed:19633174). Also plays a role in normal development of the swim bladder (PubMed:19633174).<ref>PMID:19633174</ref> <ref>PMID:31367042</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Danio rerio]]
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Fan M]]
+[[Category: Feng L]]
+[[Category: Zhang J]]