7fsl: Difference between revisions

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'''Unreleased structure'''


The entry 7fsl is ON HOLD
==SDCBP PanDDA analysis group deposition -- The PDZ domans of SDCBP in complex with Z730649594==
 
<StructureSection load='7fsl' size='340' side='right'caption='[[7fsl]], [[Resolution|resolution]] 2.38&Aring;' scene=''>
Authors: Bradshaw, W.J., Katis, V.L., Bountra, C., von Delft, F., Brennan, P.E.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[7fsl]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7FSL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7FSL FirstGlance]. <br>
Description: SDCBP PanDDA analysis group deposition --The PDZ domans of SDCBP in complex with Z730649594
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ALA:ALANINE'>ALA</scene>, <scene name='pdbligand=DGL:D-GLUTAMIC+ACID'>DGL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=NUM:N-[2-(4-hydroxyphenyl)ethyl]pyridine-2-carboxamide'>NUM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7fsl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7fsl OCA], [https://pdbe.org/7fsl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7fsl RCSB], [https://www.ebi.ac.uk/pdbsum/7fsl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7fsl ProSAT]</span></td></tr>
[[Category: Katis, V.L]]
</table>
[[Category: Von Delft, F]]
== Function ==
[[Category: Bountra, C]]
[https://www.uniprot.org/uniprot/SDCB1_HUMAN SDCB1_HUMAN] Seems to function as an adapter protein. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway.<ref>PMID:10230395</ref> <ref>PMID:11179419</ref> <ref>PMID:11498591</ref>
[[Category: Brennan, P.E]]
== References ==
[[Category: Bradshaw, W.J]]
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Bountra C]]
[[Category: Bradshaw WJ]]
[[Category: Brennan PE]]
[[Category: Katis VL]]
[[Category: Von Delft F]]

Revision as of 13:18, 15 February 2023

SDCBP PanDDA analysis group deposition -- The PDZ domans of SDCBP in complex with Z730649594SDCBP PanDDA analysis group deposition -- The PDZ domans of SDCBP in complex with Z730649594

Structural highlights

7fsl is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, , , , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

SDCB1_HUMAN Seems to function as an adapter protein. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway.[1] [2] [3]

References

  1. ↑ Fernandez-Larrea J, Merlos-Suarez A, Urena JM, Baselga J, Arribas J. A role for a PDZ protein in the early secretory pathway for the targeting of proTGF-alpha to the cell surface. Mol Cell. 1999 Apr;3(4):423-33. PMID:10230395
  2. ↑ Zimmermann P, Tomatis D, Rosas M, Grootjans J, Leenaerts I, Degeest G, Reekmans G, Coomans C, David G. Characterization of syntenin, a syndecan-binding PDZ protein, as a component of cell adhesion sites and microfilaments. Mol Biol Cell. 2001 Feb;12(2):339-50. PMID:11179419
  3. ↑ Geijsen N, Uings IJ, Pals C, Armstrong J, McKinnon M, Raaijmakers JA, Lammers JW, Koenderman L, Coffer PJ. Cytokine-specific transcriptional regulation through an IL-5Ralpha interacting protein. Science. 2001 Aug 10;293(5532):1136-8. PMID:11498591 doi:http://dx.doi.org/10.1126/science.1059157

7fsl, resolution 2.38Å

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