4q0d: Difference between revisions

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 ==Crystal structure of TS-DHFR from Cryptosporidium hominis in complex with NADPH, FdUMP, methotrexate and 2-amino-4-oxo-4,7-dihydro-pyrrolo[2,3-d]pyrimidine-methyl-phenyl-L-glutamic acid.==
-<StructureSection load='4q0d' size='340' side='right' caption='[[4q0d]], [[Resolution|resolution]] 3.45&Aring;' scene=''>
+<StructureSection load='4q0d' size='340' side='right'caption='[[4q0d]], [[Resolution|resolution]] 3.45&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4q0d]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Cryho Cryho]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q0D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Q0D FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4q0d]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Cryptosporidium_hominis Cryptosporidium hominis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q0D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Q0D FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2XB:N-{4-[(2-AMINO-4-HYDROXY-7H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)METHYL]BENZOYL}-L-GLUTAMIC+ACID'>2XB</scene>, <scene name='pdbligand=MTX:METHOTREXATE'>MTX</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=UFP:5-FLUORO-2-DEOXYURIDINE-5-MONOPHOSPHATE'>UFP</scene></td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2XB:N-{4-[(2-AMINO-4-HYDROXY-7H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)METHYL]BENZOYL}-L-GLUTAMIC+ACID'>2XB</scene>, <scene name='pdbligand=MTX:METHOTREXATE'>MTX</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=UFP:5-FLUORO-2-DEOXYURIDINE-5-MONOPHOSPHATE'>UFP</scene></td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1qzf|1qzf]], [[3hj3|3hj3]], [[3dl5|3dl5]], [[3dl6|3dl6]], [[2oip|2oip]], [[4ky8|4ky8]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4q0d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q0d OCA], [https://pdbe.org/4q0d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4q0d RCSB], [https://www.ebi.ac.uk/pdbsum/4q0d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4q0d ProSAT]</span></td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Chro.40506, TS-DHFR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=237895 CRYHO])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q0d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q0d OCA], [http://pdbe.org/4q0d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4q0d RCSB], [http://www.ebi.ac.uk/pdbsum/4q0d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4q0d ProSAT]</span></td></tr>
 </table>
-== Function ==
-[[http://www.uniprot.org/uniprot/Q5CGA3_CRYHO Q5CGA3_CRYHO]] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism (By similarity).[PIRNR:PIRNR000389]
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 20: / Line 16: @@
 </div>
 <div class="pdbe-citations 4q0d" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Cryho]]
+[[Category: Cryptosporidium hominis]]
-[[Category: Anderson, K S]]
+[[Category: Large Structures]]
-[[Category: Kumar, V P]]
+[[Category: Anderson KS]]
-[[Category: Bifunctional enzyme]]
+[[Category: Kumar VP]]
-[[Category: Oxidoreductase]]
-[[Category: Transferase]]
-[[Category: Transferase-transferase inhibitor complex]]