4pt4: Difference between revisions

← Older edit Newer edit →

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
 ==Crystal structure Analysis of N terminal region containing the dimerization domain and DNA binding domain of HU protein(Histone like protein-DNA binding) from Mycobacterium tuberculosis [H37Rv]==
-<StructureSection load='4pt4' size='340' side='right' caption='[[4pt4]], [[Resolution|resolution]] 2.04&Aring;' scene=''>
+<StructureSection load='4pt4' size='340' side='right'caption='[[4pt4]], [[Resolution|resolution]] 2.04&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4pt4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3c4i 3c4i]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PT4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PT4 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4pt4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3c4i 3c4i]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PT4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PT4 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4dky|4dky]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pt4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pt4 OCA], [https://pdbe.org/4pt4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pt4 RCSB], [https://www.ebi.ac.uk/pdbsum/4pt4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pt4 ProSAT]</span></td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Rv2986c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pt4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pt4 OCA], [http://pdbe.org/4pt4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pt4 RCSB], [http://www.ebi.ac.uk/pdbsum/4pt4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4pt4 ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/DBH_MYCTU DBH_MYCTU]] Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. Binds DNA non-specifically. Induces lymphoproliferation, particularly in health tuberculin reactors, and is immunogenic. Maybe involved in pathogenesis of inflammatory bowel disease (IBD) in patients with ulcerative colitis and Crohn disease (CD). Bound by anti-neutrophil cytoplasmic antibodies (pANCA), which are a hallmark of IBD. The binding is due to pANCA directed against HIST1H1D cross-reacting with DBH epitopes. In CD, target of a strong IgA response.<ref>PMID:10569769</ref> <ref>PMID:10645441</ref>
+[https://www.uniprot.org/uniprot/DBH_MYCTU DBH_MYCTU] Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. Binds DNA non-specifically. Induces lymphoproliferation, particularly in health tuberculin reactors, and is immunogenic. Maybe involved in pathogenesis of inflammatory bowel disease (IBD) in patients with ulcerative colitis and Crohn disease (CD). Bound by anti-neutrophil cytoplasmic antibodies (pANCA), which are a hallmark of IBD. The binding is due to pANCA directed against HIST1H1D cross-reacting with DBH epitopes. In CD, target of a strong IgA response.<ref>PMID:10569769</ref> <ref>PMID:10645441</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 24: / Line 22: @@
 __TOC__
 </StructureSection>
-[[Category: Bhowmick, T]]
+[[Category: Large Structures]]
-[[Category: Ghosh, S]]
+[[Category: Mycobacterium tuberculosis]]
-[[Category: Nagaraja, V]]
+[[Category: Bhowmick T]]
-[[Category: Ramagopal, U A]]
+[[Category: Ghosh S]]
-[[Category: Ramakumar, S]]
+[[Category: Nagaraja V]]
-[[Category: Dimerization by four helix bundle interaction]]
+[[Category: Ramagopal UA]]
-[[Category: Dna binding protein]]
+[[Category: Ramakumar S]]
-[[Category: Dna condensation]]
-[[Category: Dna-binding]]