7vcm: Difference between revisions

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== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/KBP_ECOLI KBP_ECOLI]] Highly specific potassium binding protein that is required for normal growth in the presence of high levels of external K(+). May act as a sensor of cytoplasmic K(+) concentration. Binds a single K(+) ion, which induces a large conformational change. Can also bind the larger alkali metal ions Rb(+) and Cs(+), and NH(4)(+) (PubMed:27112601). May be involved in the regulation of peptidoglycan cross-linking (PubMed:25422305).<ref>PMID:25422305</ref> <ref>PMID:27112601</ref> [[https://www.uniprot.org/uniprot/GFP_AEQVI GFP_AEQVI]] Energy-transfer acceptor. Its role is to transduce the blue chemiluminescence of the protein aequorin into green fluorescent light by energy transfer. Fluoresces in vivo upon receiving energy from the Ca(2+)-activated photoprotein aequorin.
[https://www.uniprot.org/uniprot/KBP_ECOLI KBP_ECOLI] Highly specific potassium binding protein that is required for normal growth in the presence of high levels of external K(+). May act as a sensor of cytoplasmic K(+) concentration. Binds a single K(+) ion, which induces a large conformational change. Can also bind the larger alkali metal ions Rb(+) and Cs(+), and NH(4)(+) (PubMed:27112601). May be involved in the regulation of peptidoglycan cross-linking (PubMed:25422305).<ref>PMID:25422305</ref> <ref>PMID:27112601</ref> [https://www.uniprot.org/uniprot/GFP_AEQVI GFP_AEQVI] Energy-transfer acceptor. Its role is to transduce the blue chemiluminescence of the protein aequorin into green fluorescent light by energy transfer. Fluoresces in vivo upon receiving energy from the Ca(2+)-activated photoprotein aequorin.
== References ==
== References ==
<references/>
<references/>

Revision as of 09:58, 8 February 2023

crystal structure of GINKO1crystal structure of GINKO1

Structural highlights

7vcm is a 2 chain structure with sequence from Aequorea victoria and Escherichia coli K-12. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

KBP_ECOLI Highly specific potassium binding protein that is required for normal growth in the presence of high levels of external K(+). May act as a sensor of cytoplasmic K(+) concentration. Binds a single K(+) ion, which induces a large conformational change. Can also bind the larger alkali metal ions Rb(+) and Cs(+), and NH(4)(+) (PubMed:27112601). May be involved in the regulation of peptidoglycan cross-linking (PubMed:25422305).[1] [2] GFP_AEQVI Energy-transfer acceptor. Its role is to transduce the blue chemiluminescence of the protein aequorin into green fluorescent light by energy transfer. Fluoresces in vivo upon receiving energy from the Ca(2+)-activated photoprotein aequorin.

References

  1. ↑ Bernal-Cabas M, Ayala JA, Raivio TL. The Cpx envelope stress response modifies peptidoglycan cross-linking via the L,D-transpeptidase LdtD and the novel protein YgaU. J Bacteriol. 2015 Feb;197(3):603-14. doi: 10.1128/JB.02449-14. Epub 2014 Nov 24. PMID:25422305 doi:http://dx.doi.org/10.1128/JB.02449-14
  2. ↑ Ashraf KU, Josts I, Mosbahi K, Kelly SM, Byron O, Smith BO, Walker D. The Potassium Binding Protein Kbp Is a Cytoplasmic Potassium Sensor. Structure. 2016 May 3;24(5):741-9. doi: 10.1016/j.str.2016.03.017. Epub 2016 Apr , 21. PMID:27112601 doi:http://dx.doi.org/10.1016/j.str.2016.03.017

7vcm, resolution 1.85Å

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OCA
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