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'''CRYSTAL STRUCTURE OF H9 HAEMAGGLUTININ COMPLEXED WITH LSTA RECEPTOR ANALOG''' | '''CRYSTAL STRUCTURE OF H9 HAEMAGGLUTININ COMPLEXED WITH LSTA RECEPTOR ANALOG''' | ||
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==About this Structure== | ==About this Structure== | ||
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JSH OCA]. | |||
==Reference== | ==Reference== | ||
X-ray structures of H5 avian and H9 swine influenza virus hemagglutinins bound to avian and human receptor analogs., Ha Y, Stevens DJ, Skehel JJ, Wiley DC, Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11181-6. Epub 2001 Sep 18. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11562490 11562490] | X-ray structures of H5 avian and H9 swine influenza virus hemagglutinins bound to avian and human receptor analogs., Ha Y, Stevens DJ, Skehel JJ, Wiley DC, Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11181-6. Epub 2001 Sep 18. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11562490 11562490] | ||
[[Category: Ha, Y.]] | [[Category: Ha, Y.]] | ||
[[Category: Skehel, J J.]] | [[Category: Skehel, J J.]] | ||
[[Category: Stevens, D J.]] | [[Category: Stevens, D J.]] | ||
[[Category: Wiley, D C.]] | [[Category: Wiley, D C.]] | ||
[[Category: | [[Category: Fusion protein]] | ||
[[Category: | [[Category: Influenza]] | ||
[[Category: | [[Category: Receptor complex]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:50:28 2008'' | |||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | |||
Revision as of 21:50, 2 May 2008
CRYSTAL STRUCTURE OF H9 HAEMAGGLUTININ COMPLEXED WITH LSTA RECEPTOR ANALOG
OverviewOverview
The three-dimensional structures of avian H5 and swine H9 influenza hemagglutinins (HAs) from viruses closely related to those that caused outbreaks of human disease in Hong Kong in 1997 and 1999 were determined bound to avian and human cell receptor analogs. Emerging influenza pandemics have been accompanied by the evolution of receptor-binding specificity from the preference of avian viruses for sialic acid receptors in alpha2,3 linkage to the preference of human viruses for alpha2,6 linkages. The four new structures show that HA binding sites specific for human receptors appear to be wider than those preferring avian receptors and how avian and human receptors are distinguished by atomic contacts at the glycosidic linkage. alpha2,3-Linked sialosides bind the avian HA in a trans conformation to form an alpha2,3 linkage-specific motif, made by the glycosidic oxygen and 4-OH of the penultimate galactose, that is complementary to the hydrogen-bonding capacity of Gln-226, an avian-specific residue. alpha2,6-Linked sialosides bind in a cis conformation, exposing the glycosidic oxygen to solution and nonpolar atoms of the receptor to Leu-226, a human-specific residue. The new structures are compared with previously reported crystal structures of HA/sialoside complexes of the H3 subtype that caused the 1968 Hong Kong Influenza virus pandemic and analyzed in relation to HA sequences of all 15 subtypes and to receptor affinity data to make clearer how receptor-binding sites of HAs from avian viruses evolve as the virus adapts to humans.
About this StructureAbout this Structure
Full crystallographic information is available from OCA.
ReferenceReference
X-ray structures of H5 avian and H9 swine influenza virus hemagglutinins bound to avian and human receptor analogs., Ha Y, Stevens DJ, Skehel JJ, Wiley DC, Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11181-6. Epub 2001 Sep 18. PMID:11562490 Page seeded by OCA on Fri May 2 21:50:28 2008