1jqo: Difference between revisions

Revision as of 21:40, 2 May 2008

Crystal structure of C4-form phosphoenolpyruvate carboxylase from maize

OverviewOverview

Phosphoenolpyruvate carboxylase (PEPC) catalyzes the first step in the fixation of atmospheric CO(2) during C(4) photosynthesis. The crystal structure of C(4) form maize PEPC (ZmPEPC), the first structure of the plant PEPCs, has been determined at 3.0 A resolution. The structure includes a sulfate ion at the plausible binding site of an allosteric activator, glucose 6-phosphate. The crystal structure of E. coli PEPC (EcPEPC) complexed with Mn(2+), phosphoenolpyruvate analog (3,3-dichloro-2-dihydroxyphosphinoylmethyl-2-propenoate), and an allosteric inhibitor, aspartate, has also been determined at 2.35 A resolution. Dynamic movements were found in the ZmPEPC structure, compared with the EcPEPC structure, around two loops near the active site. On the basis of these molecular structures, the mechanisms for the carboxylation reaction and for the allosteric regulation of PEPC are proposed.

About this StructureAbout this Structure

1JQO is a Single protein structure of sequence from Zea mays. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structures of C4 form maize and quaternary complex of E. coli phosphoenolpyruvate carboxylases., Matsumura H, Xie Y, Shirakata S, Inoue T, Yoshinaga T, Ueno Y, Izui K, Kai Y, Structure. 2002 Dec;10(12):1721-30. PMID:12467579 Page seeded by OCA on Fri May 2 21:40:35 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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 [[Image:1jqo.jpg|left|200px]]
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 '''Crystal structure of C4-form phosphoenolpyruvate carboxylase from maize'''
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 [[Category: Kai, Y.]]
 [[Category: Matsumura, H.]]
-[[Category: beta barrel]]
+[[Category: Beta barrel]]
-[[Category: carbon dioxide fixation]]
+[[Category: Carbon dioxide fixation]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 21:40:35 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:37:37 2008''