4oq0: Difference between revisions

No edit summary
No edit summary
Line 1: Line 1:


==Crystal structure of stabilized TEM-1 beta-lactamase variant v.13 carrying R164S/G238S mutation in complex with boron-based inhibitor EC25==
==Crystal structure of stabilized TEM-1 beta-lactamase variant v.13 carrying R164S/G238S mutation in complex with boron-based inhibitor EC25==
<StructureSection load='4oq0' size='340' side='right' caption='[[4oq0]], [[Resolution|resolution]] 1.42&Aring;' scene=''>
<StructureSection load='4oq0' size='340' side='right'caption='[[4oq0]], [[Resolution|resolution]] 1.42&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4oq0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OQ0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OQ0 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4oq0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OQ0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OQ0 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2UL:3-[(2R)-2-{[(2R)-2-AMINO-2-PHENYLACETYL]AMINO}-2-(DIHYDROXYBORANYL)ETHYL]BENZOIC+ACID'>2UL</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2UL:3-[(2R)-2-{[(2R)-2-AMINO-2-PHENYLACETYL]AMINO}-2-(DIHYDROXYBORANYL)ETHYL]BENZOIC+ACID'>2UL</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ibr|4ibr]], [[4op5|4op5]], [[4op8|4op8]], [[4opq|4opq]], [[4opr|4opr]], [[4opy|4opy]], [[4opz|4opz]], [[4oqg|4oqg]], [[4oqh|4oqh]], [[4oqi|4oqi]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4oq0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oq0 OCA], [https://pdbe.org/4oq0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4oq0 RCSB], [https://www.ebi.ac.uk/pdbsum/4oq0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4oq0 ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">bla-TEM-94 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oq0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oq0 OCA], [http://pdbe.org/4oq0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4oq0 RCSB], [http://www.ebi.ac.uk/pdbsum/4oq0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4oq0 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q8KMX3_ECOLX Q8KMX3_ECOLX]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 18: Line 18:
</div>
</div>
<div class="pdbe-citations 4oq0" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4oq0" style="background-color:#fffaf0;"></div>
==See Also==
*[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bacillus coli migula 1895]]
[[Category: Escherichia coli]]
[[Category: Dellus-Gur, E]]
[[Category: Large Structures]]
[[Category: Elias, M]]
[[Category: Dellus-Gur E]]
[[Category: Fraser, J S]]
[[Category: Elias M]]
[[Category: Tawfik, D S]]
[[Category: Fraser JS]]
[[Category: Beta-lactamase]]
[[Category: Tawfik DS]]
[[Category: Hydrolase-hydrolase inhibitor complex]]

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA