1jpy: Difference between revisions

Revision as of 21:35, 2 May 2008

Crystal structure of IL-17F

OverviewOverview

The proinflammatory cytokine interleukin 17 (IL-17) is the founding member of a family of secreted proteins that elicit potent cellular responses. We report a novel human IL-17 homolog, IL-17F, and show that it is expressed by activated T cells, can stimulate production of other cytokines such as IL-6, IL-8 and granulocyte colony-stimulating factor, and can regulate cartilage matrix turnover. Unexpectedly, the crystal structure of IL-17F reveals that IL-17 family members adopt a monomer fold typical of cystine knot growth factors, despite lacking the disulfide responsible for defining the canonical "knot" structure. IL-17F dimerizes in a parallel manner like neurotrophins, and features an unusually large cavity on its surface. Remarkably, this cavity is located in precisely the same position where nerve growth factor binds its high affinity receptor, TrkA, suggesting further parallels between IL-17s and neurotrophins with respect to receptor recognition.

About this StructureAbout this Structure

1JPY is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

IL-17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL-17F, and implications for receptor binding., Hymowitz SG, Filvaroff EH, Yin JP, Lee J, Cai L, Risser P, Maruoka M, Mao W, Foster J, Kelley RF, Pan G, Gurney AL, de Vos AM, Starovasnik MA, EMBO J. 2001 Oct 1;20(19):5332-41. PMID:11574464 Page seeded by OCA on Fri May 2 21:35:06 2008

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OCA

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 [[Image:1jpy.gif|left|200px]]
- {{Structure
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-|GENE= IL-17F ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jpy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jpy OCA], [http://www.ebi.ac.uk/pdbsum/1jpy PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1jpy RCSB]</span>
-}}
 '''Crystal structure of IL-17F'''
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 [[Category: Vos, A M.de.]]
 [[Category: Yin, J.]]
-[[Category: cystine-knot]]
+[[Category: Cystine-knot]]
-[[Category: cytokine]]
+[[Category: Cytokine]]
-[[Category: dimer]]
+[[Category: Dimer]]
-[[Category: t-cell derived]]
+[[Category: T-cell derived]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 21:35:06 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:37:12 2008''