1k24: Difference between revisions
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<StructureSection load='1k24' size='340' side='right'caption='[[1k24]], [[Resolution|resolution]] 2.03Å' scene=''> | <StructureSection load='1k24' size='340' side='right'caption='[[1k24]], [[Resolution|resolution]] 2.03Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1k24]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[1k24]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Neisseria_meningitidis Neisseria meningitidis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K24 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1K24 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k24 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k24 OCA], [https://pdbe.org/1k24 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1k24 RCSB], [https://www.ebi.ac.uk/pdbsum/1k24 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k24 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k24 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k24 OCA], [https://pdbe.org/1k24 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1k24 RCSB], [https://www.ebi.ac.uk/pdbsum/1k24 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k24 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/Q51227_NEIME Q51227_NEIME] | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Neisseria meningitidis]] | ||
[[Category: | [[Category: Achtman M]] | ||
[[Category: Derrick JP]] | |||
[[Category: | [[Category: Prince SM]] | ||
[[Category: | |||
Revision as of 10:07, 25 January 2023
Crystal Structure of the OpcA Outer Membrane Adhesin/Invasin from Neisseria meningitidisCrystal Structure of the OpcA Outer Membrane Adhesin/Invasin from Neisseria meningitidis
Structural highlights
FunctionPublication Abstract from PubMedOpcA is an integral outer membrane protein from Neisseria meningitidis, the causative agent of meningococcal meningitis and septicemia. It mediates the adhesion of N. meningitidis to epithelial and endothelial cells by binding to vitronectin and proteoglycan cell-surface receptors. Here, we report the determination of the crystal structure of OpcA to 2.0 A resolution. OpcA adopts a 10-stranded beta-barrel structure with extensive loop regions that protrude above the predicted surface of the membrane. The second external loop adopts an unusual conformation, traversing the axis of the beta-barrel and apparently blocking formation of a pore through the membrane. Loops 2, 3, 4, and 5 associate to form one side of a crevice in the external surface of the structure, the other side being formed by loop 1. The crevice is lined by positively charged residues and would form an ideal binding site for proteoglycan polysaccharide. The structure, therefore, suggests a model for how adhesion of this important human pathogen to proteoglycan is mediated at the molecular level. Crystal structure of the OpcA integral membrane adhesin from Neisseria meningitidis.,Prince SM, Achtman M, Derrick JP Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3417-21. Epub 2002 Mar 12. PMID:11891340[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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