8hy5: Difference between revisions

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'''Unreleased structure'''


The entry 8hy5 is ON HOLD
==Structure of D-amino acid oxidase mutant R38H==
 
<StructureSection load='8hy5' size='340' side='right'caption='[[8hy5]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
Authors: Khan, S., Upadhyay, S., Kumar, A., Dave, U., Gomes, J.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8hy5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8HY5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8HY5 FirstGlance]. <br>
Description: Structure of D-amino acid oxidase mutant R38H
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8hy5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8hy5 OCA], [https://pdbe.org/8hy5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8hy5 RCSB], [https://www.ebi.ac.uk/pdbsum/8hy5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8hy5 ProSAT]</span></td></tr>
[[Category: Upadhyay, S]]
</table>
[[Category: Gomes, J]]
== Function ==
[[Category: Dave, U]]
[https://www.uniprot.org/uniprot/OXDA_HUMAN OXDA_HUMAN] Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids.<ref>PMID:17303072</ref>
[[Category: Khan, S]]
== References ==
[[Category: Kumar, A]]
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Dave U]]
[[Category: Gomes J]]
[[Category: Khan S]]
[[Category: Kumar A]]
[[Category: Upadhyay S]]

Revision as of 09:38, 25 January 2023

Structure of D-amino acid oxidase mutant R38HStructure of D-amino acid oxidase mutant R38H

Structural highlights

8hy5 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

OXDA_HUMAN Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids.[1]

References

  1. ↑ Kawazoe T, Tsuge H, Imagawa T, Aki K, Kuramitsu S, Fukui K. Structural basis of D-DOPA oxidation by D-amino acid oxidase: alternative pathway for dopamine biosynthesis. Biochem Biophys Res Commun. 2007 Apr 6;355(2):385-91. Epub 2007 Feb 8. PMID:17303072 doi:10.1016/j.bbrc.2007.01.181

8hy5, resolution 2.10Å

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OCA
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