7wiw: Difference between revisions

Revision as of 09:31, 25 January 2023

Cryo-EM structure of Mycobacterium tuberculosis irtAB complexed with ATP in an occluded conformationCryo-EM structure of Mycobacterium tuberculosis irtAB complexed with ATP in an occluded conformation

Structural highlights

7wiw is a 2 chain structure with sequence from Mycobacterium tuberculosis H37Rv. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

IRTB_MYCTU Part of the ABC transporter complex IrtAB involved in the import of iron-bound mycobactin (Fe-MBT) and carboxymycobactin (Fe-cMBT) (PubMed:16385031, PubMed:19948799) (By similarity). Transmembrane domains (TMD) form a pore in the membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity). Required for replication in human macrophages and in mouse lungs (PubMed:16385031).[UniProtKB:G7CBF6]^[1] ^[2]

References

↑ Rodriguez GM, Smith I. Identification of an ABC transporter required for iron acquisition and virulence in Mycobacterium tuberculosis. J Bacteriol. 2006 Jan;188(2):424-30. doi: 10.1128/JB.188.2.424-430.2006. PMID:16385031 doi:http://dx.doi.org/10.1128/JB.188.2.424-430.2006
↑ Ryndak MB, Wang S, Smith I, Rodriguez GM. The Mycobacterium tuberculosis high-affinity iron importer, IrtA, contains an FAD-binding domain. J Bacteriol. 2010 Feb;192(3):861-9. doi: 10.1128/JB.00223-09. Epub 2009 Nov 30. PMID:19948799 doi:http://dx.doi.org/10.1128/JB.00223-09

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OCA

[1] Rodriguez GM, Smith I. Identification of an ABC transporter required for iron acquisition and virulence in Mycobacterium tuberculosis. J Bacteriol. 2006 Jan;188(2):424-30. doi: 10.1128/JB.188.2.424-430.2006. PMID:16385031 doi:http://dx.doi.org/10.1128/JB.188.2.424-430.2006

[2] Ryndak MB, Wang S, Smith I, Rodriguez GM. The Mycobacterium tuberculosis high-affinity iron importer, IrtA, contains an FAD-binding domain. J Bacteriol. 2010 Feb;192(3):861-9. doi: 10.1128/JB.00223-09. Epub 2009 Nov 30. PMID:19948799 doi:http://dx.doi.org/10.1128/JB.00223-09

[1]

[2]

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-'''Unreleased structure'''
-The entry 7wiw is ON HOLD  until Paper Publication
+==Cryo-EM structure of Mycobacterium tuberculosis irtAB complexed with ATP in an occluded conformation==
+<StructureSection load='7wiw' size='340' side='right'caption='[[7wiw]], [[Resolution|resolution]] 3.12&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[7wiw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WIW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WIW FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wiw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wiw OCA], [https://pdbe.org/7wiw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wiw RCSB], [https://www.ebi.ac.uk/pdbsum/7wiw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wiw ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/IRTB_MYCTU IRTB_MYCTU] Part of the ABC transporter complex IrtAB involved in the import of iron-bound mycobactin (Fe-MBT) and carboxymycobactin (Fe-cMBT) (PubMed:16385031, PubMed:19948799) (By similarity). Transmembrane domains (TMD) form a pore in the membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity). Required for replication in human macrophages and in mouse lungs (PubMed:16385031).[UniProtKB:G7CBF6]<ref>PMID:16385031</ref> <ref>PMID:19948799</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Mycobacterium tuberculosis H37Rv]]
+[[Category: Rao Z]]
+[[Category: Sun S]]
+[[Category: Yang H]]
+[[Category: Zhang B]]

7wiw: Difference between revisions

Revision as of 09:31, 25 January 2023

Cryo-EM structure of Mycobacterium tuberculosis irtAB complexed with ATP in an occluded conformationCryo-EM structure of Mycobacterium tuberculosis irtAB complexed with ATP in an occluded conformation

Structural highlights

Function

References

Contents

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7wiw: Difference between revisions

Revision as of 09:31, 25 January 2023

Cryo-EM structure of Mycobacterium tuberculosis irtAB complexed with ATP in an occluded conformationCryo-EM structure of Mycobacterium tuberculosis irtAB complexed with ATP in an occluded conformation

Structural highlights

Function

References

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