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==BRD3-BD1 in complex with RaPID linear peptide 2xAcK.1 (diAcK.1)== | |||
<StructureSection load='7to8' size='340' side='right'caption='[[7to8]], [[Resolution|resolution]] 1.50Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7to8]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TO8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TO8 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7to8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7to8 OCA], [https://pdbe.org/7to8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7to8 RCSB], [https://www.ebi.ac.uk/pdbsum/7to8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7to8 ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: Low | == Disease == | ||
[[Category: Patel | [https://www.uniprot.org/uniprot/BRD3_HUMAN BRD3_HUMAN] Note=A chromosomal aberration involving BRD3 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;9)(q14;q34) with NUT which produces a BRD3-NUT fusion protein. | ||
== Function == | |||
[https://www.uniprot.org/uniprot/BRD3_HUMAN BRD3_HUMAN] Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and interaction with transcription factors. Regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (By similarity). Regulates transcription of the CCND1 gene.<ref>PMID:18406326</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Synthetic construct]] | |||
[[Category: Low JKK]] | |||
[[Category: Mackay JP]] | |||
[[Category: Patel K]] | |||
Revision as of 09:30, 25 January 2023
BRD3-BD1 in complex with RaPID linear peptide 2xAcK.1 (diAcK.1)BRD3-BD1 in complex with RaPID linear peptide 2xAcK.1 (diAcK.1)
Structural highlights
DiseaseBRD3_HUMAN Note=A chromosomal aberration involving BRD3 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;9)(q14;q34) with NUT which produces a BRD3-NUT fusion protein. FunctionBRD3_HUMAN Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and interaction with transcription factors. Regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (By similarity). Regulates transcription of the CCND1 gene.[1] References
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