7qw5: Difference between revisions

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'''Unreleased structure'''


The entry 7qw5 is ON HOLD  until 2024-01-24
==Adenine-specific DNA methyltransferase M.BseCI complexed with AdoHcy and cognate unmethylated DNA duplex==
 
<StructureSection load='7qw5' size='340' side='right'caption='[[7qw5]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
Authors: Mitsikas, D.A., Kouyianou, K., Kotsifaki, D., Providaki, M., Bouriotis, V., Glykos, N.M., Kokkinidis, M.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[7qw5]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QW5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QW5 FirstGlance]. <br>
Description: Adenine-specific DNA methyltransferase M.BseCI complexed with AdoHcy and cognate unmethylated DNA duplex
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qw5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qw5 OCA], [https://pdbe.org/7qw5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qw5 RCSB], [https://www.ebi.ac.uk/pdbsum/7qw5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qw5 ProSAT]</span></td></tr>
[[Category: Bouriotis, V]]
</table>
[[Category: Glykos, N.M]]
== Function ==
[[Category: Mitsikas, D.A]]
[https://www.uniprot.org/uniprot/MTC1_GEOSE MTC1_GEOSE] A gamma subtype methylase, recognizes the double-stranded sequence 5'-ATCGAT-3', methylation on A-5 on both strands, and protects the DNA from cleavage by the BanIII endonuclease.<ref>PMID:12654995</ref>
[[Category: Providaki, M]]
== References ==
[[Category: Kouyianou, K]]
<references/>
[[Category: Kotsifaki, D]]
__TOC__
[[Category: Kokkinidis, M]]
</StructureSection>
[[Category: Geobacillus stearothermophilus]]
[[Category: Large Structures]]
[[Category: Bouriotis V]]
[[Category: Glykos NM]]
[[Category: Kokkinidis M]]
[[Category: Kotsifaki D]]
[[Category: Kouyianou K]]
[[Category: Mitsikas DA]]
[[Category: Providaki M]]

Revision as of 09:27, 25 January 2023

Adenine-specific DNA methyltransferase M.BseCI complexed with AdoHcy and cognate unmethylated DNA duplexAdenine-specific DNA methyltransferase M.BseCI complexed with AdoHcy and cognate unmethylated DNA duplex

Structural highlights

7qw5 is a 3 chain structure with sequence from Geobacillus stearothermophilus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

MTC1_GEOSE A gamma subtype methylase, recognizes the double-stranded sequence 5'-ATCGAT-3', methylation on A-5 on both strands, and protects the DNA from cleavage by the BanIII endonuclease.[1]

References

  1. ↑ Roberts RJ, Belfort M, Bestor T, Bhagwat AS, Bickle TA, Bitinaite J, Blumenthal RM, Degtyarev SKh, Dryden DT, Dybvig K, Firman K, Gromova ES, Gumport RI, Halford SE, Hattman S, Heitman J, Hornby DP, Janulaitis A, Jeltsch A, Josephsen J, Kiss A, Klaenhammer TR, Kobayashi I, Kong H, Kruger DH, Lacks S, Marinus MG, Miyahara M, Morgan RD, Murray NE, Nagaraja V, Piekarowicz A, Pingoud A, Raleigh E, Rao DN, Reich N, Repin VE, Selker EU, Shaw PC, Stein DC, Stoddard BL, Szybalski W, Trautner TA, Van Etten JL, Vitor JM, Wilson GG, Xu SY. A nomenclature for restriction enzymes, DNA methyltransferases, homing endonucleases and their genes. Nucleic Acids Res. 2003 Apr 1;31(7):1805-12. PMID:12654995

7qw5, resolution 2.30Å

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OCA
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